Csata S, Kulcsár G, Nász I
Department of Urology, István Kórház, Budapest, Hungary.
Acta Chir Hung. 1990;31(4):351-6.
During their attempts at culturing viruses from tumour cells and circulating lymphocytes, authors obtained oncogenic type 18 infectious adenovirus from the phytohaemagglutinin-stimulated, peripheral T lymphocytes of a patient with bladder tumour. They found that the lymphocytes of other patients with urogenital tumour often show sensibility to the viral antigens. The successful culturing of the virus proves that patients with urogenital tumour carry the functioning genomes of the ontogenic virus, not only in their tumour cells but also in their circulating lymphocytes. It is assumed that these genomes jointly with the immune system impaired by other DNS viruses might have a role in tumour development. It is known that the tumour cells and circulating lymphocytes of patients with malignant urogenital tumour may carry viral components, latent viruses. However, infectious virus--in the mentioned cases--could not be isolated. In the present study attempt was made to culture infectious virus from the tumour cells and the in vitro stimulated circulating T lymphocytes of patients with urogenital tumour.
在尝试从肿瘤细胞和循环淋巴细胞中培养病毒的过程中，作者从一名膀胱肿瘤患者经植物血凝素刺激的外周T淋巴细胞中获得了致癌的18型传染性腺病毒。他们发现，其他泌尿生殖系统肿瘤患者的淋巴细胞常常对病毒抗原有敏感性。病毒的成功培养证明，泌尿生殖系统肿瘤患者不仅在其肿瘤细胞中，而且在其循环淋巴细胞中都携带致癌病毒的功能性基因组。据推测，这些基因组与受其他DNA病毒损害的免疫系统共同作用，可能在肿瘤发展中起作用。众所周知，恶性泌尿生殖系统肿瘤患者的肿瘤细胞和循环淋巴细胞可能携带病毒成分，即潜伏病毒。然而，在上述病例中无法分离出传染性病毒。在本研究中，试图从泌尿生殖系统肿瘤患者的肿瘤细胞和体外刺激的循环T淋巴细胞中培养传染性病毒。
