Csata S, Kulcsár G, Dán P, Nász I, Verebélyi A
Department of Urology, István Hospital Budapest, Hungary.
Acta Chir Hung. 1987;28(4):321-5.
A considerable wealth of data suggest that a virus with oncogen character can play a part in the development or survival of tumours, by disturbing immune reaction. We studied this situation in urogenital tumours. Examining the latent virus carrier with an immunofluorescent method in 96 cases with malignant tumours and 70 control cases, it was found that more than 50% of the patients had latent adeno- or herpes simplex virus antigens in 1-3% of the circulating lymphocytes, whereas virus carriers occurred in hardly a few percent in the control group. Using a lymphocyte transformation test, the non-specific mitogen phytohaemagglutinin was able to transform only 10-50% of the lymphocytes of patients with malignant tumours into lymphoblast cells (the percentage also depending on the stage of the tumour). On the other hand, under the influence of phytohaemagglutinin 55-85% of the lymphocytes of the control group turned into lymphoblasts. The lymphocytes of the majority of patients with tumours became sensitive for specific adeno- and herpes simplex virus antigens, mainly the lymphocytes of those whose cells were virus carriers.
大量数据表明，具有致癌特性的病毒可通过干扰免疫反应，在肿瘤的发生或存活中发挥作用。我们对泌尿生殖系统肿瘤的这种情况进行了研究。采用免疫荧光法对96例恶性肿瘤患者和70例对照者进行潜伏病毒携带者检测，发现超过50%的患者循环淋巴细胞中有1% - 3%存在潜伏腺病毒或单纯疱疹病毒抗原，而对照组中病毒携带者的比例几乎不到百分之几。使用淋巴细胞转化试验，非特异性促有丝分裂原植物血凝素仅能使10% - 50%的恶性肿瘤患者的淋巴细胞转化为成淋巴细胞（该百分比也取决于肿瘤分期）。另一方面，在植物血凝素的影响下，对照组55% - 85%的淋巴细胞转化为成淋巴细胞。大多数肿瘤患者的淋巴细胞对特异性腺病毒和单纯疱疹病毒抗原敏感，主要是那些细胞为病毒携带者的患者的淋巴细胞。
