Csata S, Kulcsár G, Dán P, Horváth J, Nász I, Verebélyi A, Ongrádi J
Acta Chir Hung. 1985;26(2):119-23.
The possible connections between the oncogenic viruses and the various tumours of the urogenital system were investigated. Examining the patients' cellular immune response by the lymphocyte transformation test, it was found that the non-specific immune response was considerably diminished in almost all cases, while response to adeno- and herpesvirus antigens was enhanced. Structural and functional impairment of T-lymphocytes frequently occurred. Antiviral humoral antibodies were present more rarely in cancer patients than in the controls. However, type 12 markedly oncogenic anti-adenovirus antibody was frequently found. Using the immunofluorescent method, adeno- and herpesviruses were found in more than 50% of the patients' malignant tumour cells. Electron microscopically, in some cases adeno-, herpes- and type C virus particles, too, were isolated in the tumour cells. According to these results besides other factors also adenoviruses may play a role in urogenital tumours.
对致癌病毒与泌尿生殖系统各种肿瘤之间可能存在的联系进行了研究。通过淋巴细胞转化试验检测患者的细胞免疫反应，发现几乎在所有病例中，非特异性免疫反应都显著减弱，而对腺病毒和疱疹病毒抗原的反应增强。T淋巴细胞的结构和功能损害经常发生。癌症患者中抗病毒体液抗体的出现频率低于对照组。然而，经常发现具有明显致癌性的12型抗腺病毒抗体。采用免疫荧光法，在50%以上患者的恶性肿瘤细胞中发现了腺病毒和疱疹病毒。在电子显微镜下，在某些情况下，肿瘤细胞中也分离出了腺病毒、疱疹病毒和C型病毒颗粒。根据这些结果，除其他因素外，腺病毒也可能在泌尿生殖系统肿瘤中发挥作用。
