Haycock J W, van Buskirk R, Gold P E, McGaugh J L
Eur J Pharmacol. 1978 Oct 1;51(3):261-73. doi: 10.1016/0014-2999(78)90411-9.
Diethyldithiocarbamate (DDC) and fusaric acid (FA), administered immediately posttraining, disrupted retention performance of rats trained on a one-trial inhibitory avoidance task. Posttraining DDC disrupted retention performance if the treatment was delayed up to at least 24 h (but not 72 h) after training. A single DDC injection also disrupted retention performance if the treatment was administered up to 10 days prior to training. The effects of DDC and FA upon several neurobiological measures were also investigated. Amnestic doses of DDC influence brain and adrenal catecholamine levels, brain electrographic activity and hippocampal Timm's staining. On the other hand, amnestic doses of FA only affected catecholamine levels. The amnestic effects of DDC were dissociated from brain seizure activity produced by DDC. The effects of DDC and FA upon retention may have been related to the drugs' effects upon catecholamine systems, but the bleaching by DDC of Timm's staining could reflect additional processes involved in DDC's effects upon retention. As opposed to the more widespread effects of DDC, FA's relative lack of effect upon other neurobiological measures more strongly supports a catecholaminergic interpretation for its effect upon retention.
在一次尝试性抑制性回避任务训练后立即给予二乙基二硫代氨基甲酸盐（DDC）和镰刀菌酸（FA），会干扰大鼠的记忆保持表现。如果在训练后将DDC的处理延迟至少24小时（但不是72小时），训练后给予DDC会干扰记忆保持表现。如果在训练前10天内给予单次DDC注射，也会干扰记忆保持表现。还研究了DDC和FA对几种神经生物学指标的影响。失忆剂量的DDC会影响大脑和肾上腺儿茶酚胺水平、脑电活动以及海马体的Timm染色。另一方面，失忆剂量的FA仅影响儿茶酚胺水平。DDC的失忆作用与DDC产生的脑癫痫活动无关。DDC和FA对记忆保持的影响可能与药物对儿茶酚胺系统的作用有关，但DDC对Timm染色的漂白作用可能反映了DDC对记忆保持影响中涉及的其他过程。与DDC更广泛的作用相反，FA对其他神经生物学指标相对缺乏影响，这更有力地支持了其对记忆保持影响的儿茶酚胺能解释。
