Solanto M V, Hamburg M D
Psychopharmacology (Berl). 1979 Nov;66(2):167-70. doi: 10.1007/BF00427625.
Diethyldithiocarbamic acid (DDC), a dopamine-B-hydroxylase inhibitor, when injected into rats 30 min to 6 h before training of a passive avoidance task, impaired formation of long-term memory as indicated by performance on a retention test 24 h later. Performance of the task was at its minimum when injection occurred 2 to 4 h prior to training; recovery was evident in animals trained 5 or 6 h after drug treatment. Catecholamine assay of brains of temporally yoked animals showed that norepinephrine depletion followed a time course paralleling that of the amnesia. These findings support the hypothesis that the degree of memory storage, as reflected in performance following training in a passive avoidance task, can be directly correlated with the level of norepinephrine existing at the time of training.
二乙基二硫代氨基甲酸（DDC）是一种多巴胺-β-羟化酶抑制剂，在大鼠接受被动回避任务训练前30分钟至6小时注射，会损害长期记忆的形成，这在24小时后的记忆保持测试表现中得到体现。当在训练前2至4小时注射时，任务表现降至最低；在药物治疗后5或6小时训练的动物中，恢复明显。对时间配对动物大脑的儿茶酚胺测定表明，去甲肾上腺素耗竭的时间进程与失忆的时间进程平行。这些发现支持了这样一种假设，即在被动回避任务训练后的表现中反映出的记忆存储程度，可以与训练时存在的去甲肾上腺素水平直接相关。
