Lee Chia-Hui, Hung Yao-Ching, Huang G Steven
Institute of Nanotechnology; Department of Material Science and Engineering; National Chiao Tung University; Taiwan.
Commun Integr Biol. 2010 Nov;3(6):528-9. doi: 10.4161/cib.3.6.12749. Epub 2010 Nov 1.
Electro-magnetic fields are everywhere in our life. The strength and duration of human exposure is proportional to the degree of industrialization. The possible health hazard has been investigated for decades. C. elegans (nematode) has been a sensitive tool to study aging and development. The current study investigated the possible effects of static magnetic fields (SMFs) on the developmental and aging processes of C. elegans. Nematodes were grown in the presence of SMFs of strengths varying from 0 to 200 mT. Treatment with a 200 mT SMF reduced the development times from L2 to young adult by approximately 20%. After SMF treatment, the average lifespan was reduced from 31 days to 25 days for wild-type nematodes. The upregulation of genes associated with development and aging was verified by quantitative real-time RT-PCR. Nematodes carrying mutation in these genes also exhibited resistance to the SMFs treatment. Apparently, induction of gene expression is selective and dose-dependent. SMFs accelerate nematode development and shorten nematode lifespan through pathways associated with let-7, clk-1, unc-3 and age-1.
电磁场在我们生活中无处不在。人类暴露于电磁场的强度和时长与工业化程度成正比。其可能对健康造成的危害已被研究数十年。秀丽隐杆线虫（线虫）一直是研究衰老和发育的灵敏工具。当前研究调查了静磁场（SMF）对秀丽隐杆线虫发育和衰老过程的可能影响。线虫在强度从0至200毫特斯拉的静磁场环境中生长。用200毫特斯拉的静磁场处理使线虫从L2期发育至成虫期的时间缩短了约20%。经静磁场处理后，野生型线虫的平均寿命从31天减至25天。通过定量实时逆转录聚合酶链反应验证了与发育和衰老相关基因的上调。这些基因发生突变的线虫对静磁场处理也表现出抗性。显然，基因表达的诱导具有选择性且呈剂量依赖性。静磁场通过与let-7、clk-1、unc-3和age-1相关的途径加速线虫发育并缩短线虫寿命。
