Institutes of Physical Science and Information Technology, Anhui University, Hefei, Anhui, P.R. China.
College of Animal Science and Technology, Anhui Agricultural University, Hefei, Anhui, P.R. China.
Eur Radiol. 2024 Nov;34(11):7211-7221. doi: 10.1007/s00330-024-10819-z. Epub 2024 Jun 6.
Despite some existing studies on the safety of high static magnetic fields (SMFs), the effects of ultra-high SMFs above 20.0 T for embryonic development in early pregnancy are absent. The objective of this study is to evaluate the influence of 16.8-22.0 T SMF on the development of zebrafish embryos, which will provide important information for the future application of ultra-high field magnetic resonance imaging (MRI).
Two-hour exposure to homogenous (0 T/m) 22.0 T SMF, or 16.8 T SMFs with 123.25 T/m spatial gradient of opposite magnetic force directions was examined in the embryonic development of 200 zebrafish. Their body length, heart rate, spontaneous tail-wagging movement, hatching and survival rate, photomotor response, and visual motor response (VMR) were analyzed.
Our results show that these ultra-high SMFs did not significantly affect the general development of zebrafish embryos, such as the body length or spontaneous tail-wagging movement. However, the hatching rate was reduced by the gradient SMFs (p < 0.05), but not the homogenous 22.0 T SMF. Moreover, although the zebrafish larva activities were differentially affected by these ultra-high SMFs (p < 0.05), the expression of several visual and neurodevelopmental genes (p < 0.05) was generally downregulated in the eyeball.
Our findings suggest that exposure to ultra-high SMFs, especially the gradient SMFs, may have adverse effects on embryonic development, which should cause some attention to the future application of ultra-high field MRIs.
As technology advances, it is conceivable that very strong magnetic fields may be adapted for use in medical imaging. Possible dangers associated with these higher Tesla fields need to be considered and evaluated prior to human use.
Ultra-High static magnetic field may affect early embryonic development. High strength gradient static magnetic field exposure impacted zebrafish embryonic development. The application of very strong magnetic fields for MR technologies needs to be carefully evaluated.
尽管已有一些关于高静磁场（SMF）安全性的研究，但对于妊娠早期超高 SMF（超过 20.0 T）对胚胎发育的影响仍缺乏研究。本研究旨在评估 16.8-22.0 T SMF 对斑马鱼胚胎发育的影响，为未来超高场磁共振成像（MRI）的应用提供重要信息。
在 200 条斑马鱼的胚胎发育过程中，对其进行 2 小时的均匀（0 T/m）22.0 T SMF 暴露，或 16.8 T SMF 与 123.25 T/m 空间梯度反向磁力方向的暴露。分析其体长、心率、自发摆尾运动、孵化率和存活率、光运动反应和视觉运动反应（VMR）。
结果表明，这些超高 SMF 并未显著影响斑马鱼胚胎的一般发育，如体长或自发摆尾运动。然而，梯度 SMF 降低了孵化率（p < 0.05），但均匀的 22.0 T SMF 则没有。此外，尽管这些超高 SMF 对斑马鱼幼鱼的活动有不同的影响（p < 0.05），但眼球中的一些视觉和神经发育基因的表达普遍下调（p < 0.05）。
我们的研究结果表明，暴露于超高 SMF 中，尤其是梯度 SMF，可能对胚胎发育产生不良影响，这在未来超高场 MRI 的应用中应引起关注。
随着技术的进步，可以想象非常强的磁场可能会被用于医学成像。在将这些更高特斯拉场应用于人体之前，需要考虑并评估与之相关的潜在危险。
超高静磁场可能影响早期胚胎发育。高强度梯度静磁场暴露影响斑马鱼胚胎发育。非常强磁场在磁共振技术中的应用需要仔细评估。
