Glandt Mariela, Raz Itamar
Department of Endocrinology, Bronx-Lebanon Hospital Center, Bronx, NY 10457, USA.
J Obes. 2011;2011:636181. doi: 10.1155/2011/636181. Epub 2011 Feb 8.
Obesity now presents one of the biggest health problems of our times. Diet and exercise are best for both prevention and treatment; unfortunately, both require much discipline and are difficult to maintain. Medications offer a possible adjunct, but their effect is modest, they are limited by side effects, and the weight loss lasts only as long as the drug is being taken, since as soon as treatment is stopped, the weight is regained. Sibutramine, a sympathomimetic medication which was available for long-term treatment, is the most recent of the drugs to be withdrawn from the market due to side effects; in this case it was an increased risk of cardiovascular events. This paper reviews those medications which are available for treatment of obesity, including many of those recently taken off the market. It also discusses some of the newer treatments that are currently being investigated.
肥胖如今已成为我们这个时代最大的健康问题之一。饮食和运动对预防和治疗都最为有效；不幸的是，两者都需要很强的自律性且难以坚持。药物治疗是一种可能的辅助手段，但其效果有限，还受副作用限制，而且体重减轻仅在服药期间持续，因为一旦停止治疗，体重就会反弹。西布曲明是一种曾用于长期治疗的拟交感神经药物，它是因副作用而最近被撤出市场的最新药物；在这种情况下，其副作用是心血管事件风险增加。本文综述了可用于治疗肥胖的药物，包括许多最近已退出市场药物。此外，还讨论了目前正在研究的一些新治疗方法。
