Davison Kade, Bircher Stefan, Hill Alison, Coates Alison M, Howe Peter R C, Buckley Jonathan D
Nutritional Physiology Research Centre and ATN Centre for Metabolic Fitness, School of Health Sciences, University of South Australia, SA 5001, Australia.
J Obes. 2010;2010:191253. doi: 10.1155/2010/191253. Epub 2011 Jan 26.
Background. Obesity and low cardiorespiratory fitness (CRF) have been shown to independently increase the risk of CVD mortality. The aim of this study was to investigate the relationship between CRF, body fatness and markers of arterial function. Method and Results. Obese (9 male, 18 female; BMI 35.3 ± 0.9 kg·m(-2)) and lean (8 male, 18 female; BMI 22.5 ± 0.3 kg·m(-2)) volunteers were assessed for body composition (DXA), cardiorespiratory fitness (predicted V˙O2max), blood pressure (BP), endothelial vasodilatator function (FMD), and arterial compliance (AC) (via radial artery tonometry). The obese group had more whole body fat and abdominal fat (43.5 ± 1.2% versus 27.2 ± 1.6%; P < .001 and 48.6 ± 0.9% versus 28.9 ± 1.8%; P < .001, resp.), and lower FMD (3.2 ± 0.4% versus 5.7 ± 0.7%; P < .01) than the lean subjects, but there was no difference in AC. AC in large arteries was positively associated with CRF (R = 0.5; P < .01) but not with fatness. Conclusion. These results indicate distinct influences of obesity and CRF on blood vessel health. FMD was impaired with obesity, which may contribute to arterial and metabolic dysfunction. Low CRF was associated with reduced elasticity in large arteries, which could result in augmentation of aortic afterload.
背景。肥胖和低心肺适能（CRF）已被证明会独立增加心血管疾病（CVD）死亡风险。本研究的目的是调查CRF、体脂与动脉功能标志物之间的关系。方法与结果。对肥胖（9名男性，18名女性；BMI 35.3±0.9 kg·m⁻²）和消瘦（8名男性，18名女性；BMI 22.5±0.3 kg·m⁻²）志愿者进行身体成分（双能X线吸收法）、心肺适能（预测的最大摄氧量）、血压（BP）、内皮血管舒张功能（FMD）和动脉顺应性（AC）（通过桡动脉张力测定法）评估。肥胖组的全身脂肪和腹部脂肪更多（分别为43.5±1.2%对27.2±1.6%；P<.001和48.6±0.9%对28.9±1.8%；P<.001），且FMD低于消瘦受试者（3.2±0.4%对5.7±0.7%；P<.01），但AC无差异。大动脉的AC与CRF呈正相关（R = 0.5；P<.01），但与体脂无关。结论。这些结果表明肥胖和CRF对血管健康有不同影响。肥胖会损害FMD，这可能导致动脉和代谢功能障碍。低CRF与大动脉弹性降低有关，这可能导致主动脉后负荷增加。
