Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.
Int J Tuberc Lung Dis. 2011 Mar;15(3):369-74.
Human neutrophil peptides 1, 2 and 3 (HNP1-3) are involved in innate host defence and acquired immune response, which is possibly associated with the genesis of multidrug-resistant tuberculosis (MDR-TB).
To investigate the relationship between HNP1-3 and MDR-TB.
We divided 42 patients with post-primary pulmonary TB into two groups according to their drug susceptibility test results: the drug-susceptible group (n = 21) and the MDR-TB group (n = 21). The concentration of HNP1-3 in the plasma of all specimens was measured by enzyme-linked immunosorbent assay before treatment and 6, 18 and 24 months after. Duration of Mycobacterium tuberculosis in sputum and peripheral blood neutrophil counts were measured at the same time.
Before treatment, the plasma HNP1-3 concentration in the MDR-TB group was lower than that of healthy controls and the drug-susceptible group. After treatment, plasma HNP1-3 concentrations were higher than pre-treatment levels in the MDR-TB group, but were still lower than in healthy controls or the drug-susceptible group. The concentration of HNP1-3 was negatively correlated with the duration of M. tuberculosis in sputum, while it was positively correlated with neutrophils.
MDR-TB is associated with low plasma concentrations of HNP1-3.
人中性粒细胞肽 1、2 和 3（HNP1-3）参与先天宿主防御和获得性免疫反应，这可能与耐多药结核病（MDR-TB）的发生有关。
研究 HNP1-3 与 MDR-TB 的关系。
我们根据药敏试验结果将 42 例继发型肺结核患者分为两组：药敏组（n=21）和 MDR-TB 组（n=21）。所有标本在治疗前及治疗后 6、18 和 24 个月时，采用酶联免疫吸附试验测定血浆中 HNP1-3 的浓度。同时检测痰中分枝杆菌持续时间和外周血中性粒细胞计数。
治疗前，MDR-TB 组血浆 HNP1-3 浓度低于健康对照组和药敏组。治疗后，MDR-TB 组血浆 HNP1-3 浓度高于治疗前，但仍低于健康对照组或药敏组。HNP1-3 浓度与痰中分枝杆菌持续时间呈负相关，与中性粒细胞呈正相关。
MDR-TB 与血浆中 HNP1-3 浓度降低有关。
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