CeMM Research Center for Molecular Medicine of the Austrian Academy of Science, Lazarettgasse 14, AKH-BT25.3, 1090 Vienna, Austria.
Semin Cell Dev Biol. 2011 Jun;22(4):328-35. doi: 10.1016/j.semcdb.2011.02.018. Epub 2011 Feb 17.
Genomic imprinting is a developmentally regulated epigenetic phenomenon. The majority of imprinted genes only show parent-of-origin specific expression in a subset of tissues or at defined developmental stages. In some cases, imprinted expression is controlled by an imprinted macro non-coding RNA (ncRNA) whose expression pattern and repressive activity does not necessarily correlate with that of the genes whose imprinted expression it controls. This suggests that developmentally regulated factors other than the macro ncRNA are involved in establishing or maintaining imprinted expression. Here, we review how macro ncRNAs control imprinted expression during development and differentiation and consider how this impacts on target choice in epigenetic therapy.
基因组印迹是一种发育调控的表观遗传现象。大多数印迹基因仅在某些组织或特定发育阶段表现出亲本来源特异性表达。在某些情况下，印迹表达受印迹的大型非编码 RNA（ncRNA）控制，其表达模式和抑制活性不一定与它所控制的基因的印迹表达相关。这表明，除了大型 ncRNA 之外，发育调节因子也参与了建立或维持印迹表达。在这里，我们回顾了大型 ncRNA 如何在发育和分化过程中控制印迹表达，并考虑了这如何影响表观遗传治疗中的靶标选择。
