Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY, United States.
Neuroscience. 2013 Apr 3;235:200-14. doi: 10.1016/j.neuroscience.2013.01.022. Epub 2013 Jan 18.
Long noncoding RNAs (lncRNAs) have emerged as an important class of molecules that regulate gene expression at epigenetic, transcriptional, and post-transcriptional levels through a wide array of mechanisms. This regulation is of particular importance in the central nervous system (CNS), where precise modulation of gene expression is required for proper neuronal and glial production, connection and function. There are relatively few functional studies that characterize lncRNA mechanisms, but possible functions can often be inferred based on existing examples and the lncRNA's relative genomic position. In this review, we will discuss mechanisms of lncRNAs as predicted by genomic contexts and the possible impact on CNS development, function, and disease pathogenesis. There is no doubt that investigation of the mechanistic role of lncRNAs will open a new and exciting direction in studying CNS development and function.
长链非编码 RNA（lncRNA）已成为一类重要的分子，通过多种机制在表观遗传、转录和转录后水平上调节基因表达。这种调节在中枢神经系统（CNS）中尤为重要，在中枢神经系统中，需要精确调节基因表达才能正常产生神经元和神经胶质细胞、连接和功能。目前只有相对较少的功能研究可以描述 lncRNA 的机制，但通常可以根据现有实例和 lncRNA 的相对基因组位置推断其可能的功能。在这篇综述中，我们将讨论根据基因组背景预测的 lncRNA 机制及其对 CNS 发育、功能和疾病发病机制的可能影响。毫无疑问，研究 lncRNA 的机制作用将为研究 CNS 发育和功能开辟一个新的、令人兴奋的方向。
