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[慢性阻塞性肺疾病急性加重和住院的影响]

[Impact of exacerbations and admissions in chronic obstructive pulmonary disease].

作者信息

Arnedillo Muñoz Aurelio

机构信息

UGC de Neumología y Alergia, Hospital Universitario Puerta del Mar, Cádiz, Spain.

出版信息

Arch Bronconeumol. 2010;46 Suppl 8:8-14. doi: 10.1016/S0300-2896(10)70061-2.

Abstract

During the natural history of patients with chronic obstructive pulmonary disease (COPD), an increase in symptom severity can occur, called exacerbated COPD (ECOPD), sometimes requiring hospital admission. Although there is ongoing debate on the definition of ECOPD--leading to a lack of homogeneity in the numerous studies performed--exacerbations negatively affect patients, producing clinical and pulmonary function deterioration in the long term. Exacerbations also decrease quality of life in the medium- and long-term and have a high social and health cost, especially during hospital admission. Finally, ECOPD increases mortality in patients in the short-term, during hospital admission, and after discharge. In view of all of the above, prevention of ECOPD has become one of the main objectives in these patients.

摘要

在慢性阻塞性肺疾病(COPD)患者的自然病程中,症状严重程度可能会增加,即慢性阻塞性肺疾病急性加重(ECOPD),有时需要住院治疗。尽管关于ECOPD的定义仍在争论中,这导致众多研究缺乏同质性,但急性加重对患者产生负面影响,长期会导致临床和肺功能恶化。急性加重在中长期还会降低生活质量,并且具有高昂的社会和健康成本,尤其是在住院期间。最后,ECOPD在短期、住院期间及出院后会增加患者死亡率。鉴于上述所有情况,预防ECOPD已成为这些患者的主要目标之一。

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