Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O’Hara Street, Pittsburgh, PA 15213-2593, USA.
J Am Acad Child Adolesc Psychiatry. 2011 Mar;50(3):262-71. doi: 10.1016/j.jaac.2010.12.004. Epub 2011 Jan 20.
To evaluate the association between prenatal alcohol exposure and the rate of conduct disorder in exposed compared with unexposed adolescents.
Data for these analyses are from a longitudinal study of prenatal substance exposures. Women were interviewed at their fourth and seventh prenatal months, and with their children, at birth, 8 and 18 months, 3, 6, 10, 14, and 16 years postpartum. Offspring were interviewed with the Diagnostic Interview Schedule-IV; maternal and adolescent diagnoses were made using DSM-IV criteria at age 16 years. The sample was 592 adolescents and their mothers or caretakers.
Prenatal alcohol exposure is significantly associated with an increased rate of conduct disorder in the adolescents. This effect was detected above an average exposure of one or more drinks per day in the first trimester. The effect remained significant after controlling for other significant variables including measures of the environment, maternal psychopathology, and other prenatal exposures.
Prenatal alcohol use in the first trimester is a risk factor for conduct disorder in the exposed offspring.
评估与未暴露于酒精的青少年相比，产前酒精暴露与行为障碍发生率之间的关系。
这些分析的数据来自于一项对产前物质暴露的纵向研究。女性在第四个和第七个月接受访谈，并在孩子出生、8 个月、18 个月、3 岁、6 岁、10 岁、14 岁和 16 岁时接受访谈。使用 DSM-IV 标准对青少年进行了诊断访谈表-IV 访谈；在 16 岁时，根据 DSM-IV 标准对母亲和青少年进行诊断。样本包括 592 名青少年及其母亲或监护人。
产前酒精暴露与青少年行为障碍发生率的增加显著相关。这种影响在第一个三个月中每天饮用一杯或更多饮料的平均暴露量之上被检测到。在控制了环境、母亲精神病理学和其他产前暴露等其他重要变量后，这种影响仍然显著。
第一个三个月的产前酒精使用是暴露后代行为障碍的一个风险因素。
