Department of Paediatrics, Gastroenterology and Allergic Diseases, The Medical University of Białystok, Poland.
Neuropeptides. 2011 Jun;45(3):189-95. doi: 10.1016/j.npep.2011.01.005. Epub 2011 Feb 21.
Casein-derived peptides have been suggested to play a role in sudden infant death syndrome (SIDS). In this study, we have determined the content of bovine β-casomorphin-7 (bBCM-7) and the activity of dipeptidyl peptidase-IV (DPPIV) in sera of infants with apparent life threatening events (ALTE syndromes, 'near miss SIDS'). We have found that the sera of some infants after an apnoea event contained more β-casomorphin-7 than that of the healthy infants in the same age. In all the children after an apnoea event, however, a lowered DPPIV was detected. We suspect that the low activity of that peptidase may be responsible for opioid-induced respiratory depression, induced by bBCM-7 in the general circulation.
酪蛋白衍生肽被认为在婴儿猝死综合征（SIDS）中发挥作用。在这项研究中，我们测定了表现出危及生命的呼吸暂停事件（ALTE 综合征，“疑似 SIDS”）婴儿血清中的牛 β-酪啡肽-7（bBCM-7）含量和二肽基肽酶-IV（DPPIV）活性。我们发现，一些发生呼吸暂停事件的婴儿血清中的 β-酪啡肽-7含量高于同龄健康婴儿。然而，在所有发生呼吸暂停事件的儿童中，均检测到 DPPIV 活性降低。我们怀疑该肽酶的低活性可能是由 bBCM-7 在全身循环中引起的阿片类药物诱导的呼吸抑制所致。
