Li Jing, Yang Tingting, Sheng Xiaoyang
Department of Neonatology, School of Medicine, Shanghai First Maternity and Infant Hospital Tongji University Shanghai China.
Shanghai Weierkang Pediatric Outpatient Department Shanghai China.
Food Sci Nutr. 2025 Jul 15;13(7):e70606. doi: 10.1002/fsn3.70606. eCollection 2025 Jul.
Consumption of milk free of A1-type β-casein (A1PF) can result in reduced gastrointestinal/inflammatory symptoms versus conventional milk (containing A1- and A2-type β-casein; CON); however, the comparative effects of infant formula made with these milks are unknown. This study compared growth, gastrointestinal tolerance, and crying frequency/duration in healthy Chinese infants aged 3-4 months who consumed both breastmilk and A1PF or CON infant formula. This open-label, randomized, controlled trial conducted between July and November 2023 evaluated anthropometric measurements and comfort (Infant Gastrointestinal Symptom Questionnaire [IGSQ] and frequency of crying) of mixed-fed infants who also consumed A1PF or CON infant formula. Eczema/dermatitis severity, quality of life, satisfaction with the formula, and adverse events were also assessed. In the A1PF ( = 140) and CON groups ( = 140), the mean (standard deviation) ages were 100.83 (15.01) and 99.28 (13.15) days, respectively. There were no significant between-group differences in any anthropometric measurements. At Weeks 2 and 4, the A1PF group had significantly lower mean daily total IGSQ scores; lower mean stooling, spitting up/vomiting, crying, and fussiness domain scores; and fewer daily crying episodes than the CON group ( < 0.05). From satisfaction surveys, a significantly higher percentage of the A1PF group had relieved gastrointestinal symptoms, reduced vomiting after feeding, improved digestion, and better stool characteristics ( < 0.05). Both formulas were generally well tolerated. Among mixed-fed infants, those who consumed A1PF infant formula had the same growth as those fed CON infant formula, and improved comfort (including relieved gastrointestinal symptoms and fewer crying episodes). ClinicalTrials.gov, NCT06256094.
与传统牛奶（含A1型和A2型β-酪蛋白；CON）相比，食用不含A1型β-酪蛋白的牛奶（A1PF）可减少胃肠道/炎症症状；然而，用这些牛奶制成的婴儿配方奶粉的比较效果尚不清楚。本研究比较了3至4个月大、同时食用母乳和A1PF或CON婴儿配方奶粉的健康中国婴儿的生长情况、胃肠道耐受性以及哭闹频率/时长。这项在2023年7月至11月期间进行的开放标签、随机对照试验评估了同时食用A1PF或CON婴儿配方奶粉的混合喂养婴儿的人体测量指标和舒适度（婴儿胃肠道症状问卷[IGSQ]和哭闹频率）。还评估了湿疹/皮炎严重程度、生活质量、对配方奶粉的满意度以及不良事件。在A1PF组（n = 140）和CON组（n = 140）中，平均（标准差）年龄分别为100.83（15.01）天和99.28（13.15）天。两组在任何人体测量指标上均无显著差异。在第2周和第4周时，A1PF组的平均每日IGSQ总分显著更低；平均排便、吐奶/呕吐、哭闹和烦躁领域得分更低；且每日哭闹次数比CON组更少（P < 0.05）。从满意度调查来看，A1PF组中胃肠道症状缓解、喂食后呕吐减少、消化改善且大便性状更好的百分比显著更高（P < 0.05）。两种配方奶粉总体耐受性良好。在混合喂养婴儿中，食用A1PF婴儿配方奶粉的婴儿与食用CON婴儿配方奶粉的婴儿生长情况相同，且舒适度有所改善（包括胃肠道症状缓解和哭闹次数减少）。ClinicalTrials.gov，NCT06256094。
