Mercado M, Yu V Y, Gill A
Department of Paediatrics, Monash Medical Centre, Clayton, Victoria, Australia.
J Singapore Paediatr Soc. 1990;32(3-4):137-43.
Infants below 1500 g at birth were randomly assigned to receive one of two preterm infant formulars: S26 Low Birthweight (S26-LBW, 25 infants) or Enfalac Premature (EPF, 24 infants). They were either exclusively formula-fed (13 infants) or the formula was used to supplement their own mother's fresh breast milk (36 infants). The mean age when milk feeds were commenced was 7 days and the mean age when birthweight was regained was 12 days. The mean age when 2000 g was reached was 45 days at which time 10 (20%) infants were below the tenth centile on the intrauterine growth chart. None of the above variables were significantly different between the S26-LBW and EPF groups. However, the S26-LBW group established full enteral feeding significantly earlier compared to the EPF group (42 versus 64 d) and the number with adverse gastrointestinal effects was lower (4 versus 10 infants). Both preterm infant formulas supported a growth rate in excess of that in utero without stressing the infants' metabolic system. The growth rate of infants fed preterm breast milk supplemented with preterm infant formula was quantitatively similar to those exclusively fed preterm infant formula.
出生体重低于1500克的婴儿被随机分配接受两种早产儿配方奶粉中的一种：惠氏金装低体重儿奶粉（S26-LBW，25名婴儿）或美赞臣早产奶粉（EPF，24名婴儿）。他们要么完全采用配方奶喂养（13名婴儿），要么用配方奶补充其母亲的新鲜母乳（36名婴儿）。开始喂奶的平均年龄为7天，恢复出生体重的平均年龄为12天。达到2000克的平均年龄为45天，此时有10名（20%）婴儿在宫内生长图表上低于第十百分位。上述变量在S26-LBW组和EPF组之间均无显著差异。然而，与EPF组相比，S26-LBW组更早建立完全肠内喂养（42天对64天），且胃肠道不良反应的婴儿数量更少（4名对10名婴儿）。两种早产儿配方奶粉均支持超过宫内生长速度的生长速率，且不会给婴儿的代谢系统造成负担。补充了早产儿配方奶粉的早产母乳喂养婴儿的生长速度在数量上与完全采用早产儿配方奶粉喂养的婴儿相似。
