基于 ESIPT 开环在水中的高选择性焦磷酸传感器。
A highly selective pyrophosphate sensor based on ESIPT turn-on in water.
机构信息
Department of Chemistry and Maurice Morton Institute of Polymer Science, The University of Akron, Akron, Ohio 44325, United States.
出版信息
Org Lett. 2011 Mar 18;13(6):1362-5. doi: 10.1021/ol200054w. Epub 2011 Feb 21.
Pyrophosphate (PPi) is a biologically important target. A binuclear system 3•2Zn is found to selectively recognize PPi, leading to a ratiometric fluorescent sensor at pH 7.4 in water. The binding event triggered a large fluorescence response (∼100 nm bathochromic shift) by turning on the excited state intramolecular proton transfer (ESIPT). Detection of PPi released from a PCR experiment indicated that this new probe could be a useful tool in bioanalytical applications.
焦磷酸（PPi）是一个重要的生物靶标。研究发现，双核体系 3•2Zn 能够选择性识别 PPi，在 pH 值为 7.4 的水中形成比率型荧光传感器。该结合事件通过开启激发态分子内质子转移（ESIPT）引发了较大的荧光响应（~100nm 红移）。从 PCR 实验中释放的 PPi 的检测表明，这种新的探针可以成为生物分析应用中的有用工具。
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