Minnesota Department of Health, Immunization, Tuberculosis and International Health, 625 Robert St N, Saint Paul, MN 55164, USA.
Pediatrics. 2011 Mar;127(3):e707-12. doi: 10.1542/peds.2010-2129. Epub 2011 Feb 21.
We sought to assess Haemophilus influenzae type b (Hib) vaccination coverage in diverse areas of the United States during the 2008-2009 Hib vaccine shortage. Interim recommendations for Hib vaccination during the shortage called for deferral of the booster dose only among children not at high risk for disease; the primary series given during the first year of life continued to be recommended for all children.
Vaccination data on ∼123,000 children were collected from 8 Immunization Information System (IIS) sentinel sites. Completion of the primary Hib series (with 2 or 3 doses depending on vaccine type) by 9 months old during the vaccine shortage was compared with coverage of 2 vaccines given at similar ages (7-valent pneumococcal conjugate vaccine and diphtheria, tetanus acellular pertussis vaccine) in children born between November 1, 2007, and March 31, 2008.
During the shortage period, Hib vaccination coverage for the primary series was 7.8 to 10.3 percentage points lower than diphtheria, tetanus acellular pertussis vaccine and 7-valent pneumococcal conjugate vaccine coverage for children by the age of 9 months in 7 of 8 sentinel sites.
A significant decrease in Hib vaccination coverage for the primary series was observed and was consistent across several US localities. Close collaboration between the public health community and vaccine providers is essential during vaccine shortages to ensure that interim vaccination recommendations are clear, widely disseminated, and closely followed, and that access to available vaccine supplies is maintained.
我们旨在评估 2008-2009 年乙型流感嗜血杆菌(Hib)疫苗短缺期间美国不同地区的 Hib 疫苗接种覆盖率。在短缺期间,Hib 疫苗接种的临时建议仅针对疾病风险低的儿童推迟加强剂量;建议所有儿童在第一年继续接种主要系列疫苗。
从 8 个免疫信息系统(IIS)监测点收集了约 123000 名儿童的疫苗接种数据。在疫苗短缺期间,9 个月龄时完成主要 Hib 系列(根据疫苗类型接种 2 或 3 剂)的情况与在 2007 年 11 月 1 日至 2008 年 3 月 31 日期间出生的儿童在类似年龄(7 价肺炎球菌结合疫苗和白喉、破伤风无细胞百日咳疫苗)接种 2 种疫苗的覆盖率进行了比较。
在短缺期间,在 8 个监测点中的 7 个监测点,主要 Hib 系列疫苗的接种覆盖率比白喉、破伤风无细胞百日咳疫苗和 7 价肺炎球菌结合疫苗的接种覆盖率低 7.8 至 10.3 个百分点,在 9 个月龄的儿童中。
观察到主要 Hib 系列疫苗接种覆盖率显著下降,并且在美国几个地区都一致。在疫苗短缺期间,公共卫生界和疫苗提供者之间必须密切合作,以确保临时疫苗接种建议明确、广泛传播并得到密切遵循,并保持对现有疫苗供应的获取。