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与来自平滑肌瘤的细胞相比，松弛素可增加来自子宫肌层的平滑肌细胞中的弹性蛋白酶活性和蛋白酶抑制剂。

Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas.

作者信息

Chen Bertha, Wen Yan, Yu Xiao Yun, Polan Mary Lake

机构信息

Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.

出版信息

Fertil Steril. 2009 Apr;91(4 Suppl):1351-4. doi: 10.1016/j.fertnstert.2008.03.043. Epub 2008 Jun 12.

DOI:10.1016/j.fertnstert.2008.03.043
PMID:18554597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2728012/
Abstract

We investigated the effect of relaxin on extracellular matrix remodeling in cultured myometrial compared with leiomyoma smooth muscle cells. Relaxin increases elastase activity and protease inhibitor expressions in myometrial smooth muscle cells, but no effect was observed in leiomyoma cells.

摘要

我们研究了与子宫肌瘤平滑肌细胞相比，松弛素对培养的子宫肌层细胞外基质重塑的影响。松弛素可增加子宫肌层平滑肌细胞中的弹性蛋白酶活性和蛋白酶抑制剂表达，但在子宫肌瘤细胞中未观察到效果。

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Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas.与来自平滑肌瘤的细胞相比，松弛素可增加来自子宫肌层的平滑肌细胞中的弹性蛋白酶活性和蛋白酶抑制剂。
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2
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本文引用的文献

1
Leiomyomata uteri: hormonal and molecular determinants of growth.子宫肌瘤：生长的激素和分子决定因素
J Natl Med Assoc. 2007 Oct;99(10):1170-84.
2
Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium.子宫平滑肌瘤及相应子宫肌层中基质金属蛋白酶-2和-9的活性及其组织抑制剂的含量
Gynecol Endocrinol. 2007 Sep;23(9):541-6. doi: 10.1080/09513590701557416.
3
Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas.左炔诺孕酮宫内缓释系统及孕激素受体调节剂CDB - 2914对子宫肌瘤的影响。
Contraception. 2007 Jun;75(6 Suppl):S99-103. doi: 10.1016/j.contraception.2007.01.025. Epub 2007 Mar 21.
4
Increased expression of latent TGF-beta binding protein-1 and fibrillin-1 in human uterine leiomyomata.人子宫平滑肌瘤中潜伏性转化生长因子β结合蛋白-1和原纤维蛋白-1表达增加。
Mol Hum Reprod. 2007 May;13(5):343-9. doi: 10.1093/molehr/gam007. Epub 2007 Mar 14.
5
The role of neutrophil elastase in elastin metabolism of pelvic tissues from women with stress urinary incontinence.中性粒细胞弹性蛋白酶在压力性尿失禁女性盆底组织弹性蛋白代谢中的作用
Neurourol Urodyn. 2007;26(2):274-9. doi: 10.1002/nau.20347.
6
Volume change of uterine myomas during pregnancy: do myomas really grow?子宫肌瘤在孕期的体积变化：肌瘤真的会生长吗？
J Minim Invasive Gynecol. 2006 Sep-Oct;13(5):386-90. doi: 10.1016/j.jmig.2006.04.003.
7
In vitro culture significantly alters gene expression profiles and reduces differences between myometrial and fibroid smooth muscle cells.体外培养显著改变基因表达谱，并减少子宫肌层和平滑肌瘤平滑肌细胞之间的差异。
Mol Hum Reprod. 2006 Mar;12(3):187-207. doi: 10.1093/molehr/gal018. Epub 2006 Mar 8.
8
Spatial differences in biologic activity of large uterine leiomyomata.大型子宫平滑肌瘤生物活性的空间差异。
Fertil Steril. 2006 Jan;85(1):179-87. doi: 10.1016/j.fertnstert.2005.07.1294.
9
Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?盆腔组织中的弹性蛋白代谢：它是否受生殖激素调节？
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10
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Hum Reprod Update. 2004 May-Jun;10(3):207-20. doi: 10.1093/humupd/dmh019.