与来自平滑肌瘤的细胞相比，松弛素可增加来自子宫肌层的平滑肌细胞中的弹性蛋白酶活性和蛋白酶抑制剂。
Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas.
作者信息
Chen Bertha, Wen Yan, Yu Xiao Yun, Polan Mary Lake
机构信息
Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, USA.
出版信息
Fertil Steril. 2009 Apr;91(4 Suppl):1351-4. doi: 10.1016/j.fertnstert.2008.03.043. Epub 2008 Jun 12.
Abstract
We investigated the effect of relaxin on extracellular matrix remodeling in cultured myometrial compared with leiomyoma smooth muscle cells. Relaxin increases elastase activity and protease inhibitor expressions in myometrial smooth muscle cells, but no effect was observed in leiomyoma cells.
摘要
我们研究了与子宫肌瘤平滑肌细胞相比，松弛素对培养的子宫肌层细胞外基质重塑的影响。松弛素可增加子宫肌层平滑肌细胞中的弹性蛋白酶活性和蛋白酶抑制剂表达，但在子宫肌瘤细胞中未观察到效果。
相似文献
1
Relaxin increases elastase activity and protease inhibitors in smooth muscle cells from the myometrium compared with cells from leiomyomas.与来自平滑肌瘤的细胞相比，松弛素可增加来自子宫肌层的平滑肌细胞中的弹性蛋白酶活性和蛋白酶抑制剂。
Fertil Steril. 2009 Apr;91(4 Suppl):1351-4. doi: 10.1016/j.fertnstert.2008.03.043. Epub 2008 Jun 12.
2
Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?盆腔组织中的弹性蛋白代谢：它是否受生殖激素调节？
Am J Obstet Gynecol. 2005 May;192(5):1605-13. doi: 10.1016/j.ajog.2004.11.027.
3
Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium.子宫平滑肌瘤及相应子宫肌层中基质金属蛋白酶-2和-9的活性及其组织抑制剂的含量
Gynecol Endocrinol. 2007 Sep;23(9):541-6. doi: 10.1080/09513590701557416.
4
Differential effects of tumor necrosis factor-α on matrix metalloproteinase-2 expression in human myometrial and uterine leiomyoma smooth muscle cells.肿瘤坏死因子-α对人子宫肌层和平滑肌瘤平滑肌细胞中基质金属蛋白酶-2表达的不同影响。
Hum Reprod. 2015 Jan;30(1):61-70. doi: 10.1093/humrep/deu300. Epub 2014 Nov 14.
5
Locostatin, a disrupter of Raf kinase inhibitor protein, inhibits extracellular matrix production, proliferation, and migration in human uterine leiomyoma and myometrial cells.洛考他汀是一种Raf激酶抑制蛋白的破坏剂，可抑制人子宫平滑肌瘤和子宫肌层细胞的细胞外基质产生、增殖和迁移。
Fertil Steril. 2016 Nov;106(6):1530-1538.e1. doi: 10.1016/j.fertnstert.2016.08.010. Epub 2016 Aug 24.
6
CCNs, fibulin-1C and S100A4 expression in leiomyoma and myometrium: inverse association with TGF-beta and regulation by TGF-beta in leiomyoma and myometrial smooth muscle cells.CCNs、纤连蛋白-1C和S100A4在平滑肌瘤和子宫肌层中的表达：与转化生长因子-β呈负相关以及在平滑肌瘤和子宫肌层平滑肌细胞中受转化生长因子-β调控
Mol Hum Reprod. 2006 Apr;12(4):245-56. doi: 10.1093/molehr/gal015. Epub 2006 Mar 29.
7
Modelling fibroid pathology: development and manipulation of a myometrial smooth muscle cell macromolecular crowding model to alter extracellular matrix deposition.模拟纤维瘤病理学：肌层平滑肌细胞高分子拥挤模型的开发和操作，以改变细胞外基质的沉积。
Mol Hum Reprod. 2020 Jul 1;26(7):498-509. doi: 10.1093/molehr/gaaa036.
8
In vitro effects of phthalate esters in human myometrial and leiomyoma cells and increased urinary level of phthalate metabolite in women with uterine leiomyoma.邻苯二甲酸酯对人子宫肌层和平滑肌瘤细胞的体外作用以及子宫肌瘤女性尿中邻苯二甲酸酯代谢物水平的升高。
Fertil Steril. 2017 Apr;107(4):1061-1069.e1. doi: 10.1016/j.fertnstert.2017.01.015. Epub 2017 Mar 11.
9
Isolation and characterization of heparin-binding growth factors in human leiomyomas and normal myometrium.人平滑肌瘤和正常子宫肌层中肝素结合生长因子的分离与鉴定
Biol Reprod. 1995 Sep;53(3):636-46. doi: 10.1095/biolreprod53.3.636.
10
Differential expression of caveolin-1 in human myometrial and uterine leiomyoma smooth muscle.人子宫平滑肌和子宫肌瘤平滑肌中窖蛋白-1的差异表达。
Am J Obstet Gynecol. 2014 Nov;211(5):496.e1-496.e13. doi: 10.1016/j.ajog.2014.06.007. Epub 2014 Jun 5.
引用本文的文献
1
Trends in serum relaxin concentration among elite collegiate female athletes.精英大学女性运动员血清松弛素浓度的变化趋势。
Int J Womens Health. 2011 Jan 19;3:19-24. doi: 10.2147/IJWH.S14188.
本文引用的文献
1
Leiomyomata uteri: hormonal and molecular determinants of growth.子宫肌瘤：生长的激素和分子决定因素
J Natl Med Assoc. 2007 Oct;99(10):1170-84.
2
Activity of matrix metalloproteinase-2 and -9 and contents of their tissue inhibitors in uterine leiomyoma and corresponding myometrium.子宫平滑肌瘤及相应子宫肌层中基质金属蛋白酶-2和-9的活性及其组织抑制剂的含量
Gynecol Endocrinol. 2007 Sep;23(9):541-6. doi: 10.1080/09513590701557416.
3
Effects of levonorgestrel-releasing IUS and progesterone receptor modulator PRM CDB-2914 on uterine leiomyomas.左炔诺孕酮宫内缓释系统及孕激素受体调节剂CDB - 2914对子宫肌瘤的影响。
Contraception. 2007 Jun;75(6 Suppl):S99-103. doi: 10.1016/j.contraception.2007.01.025. Epub 2007 Mar 21.
4
Increased expression of latent TGF-beta binding protein-1 and fibrillin-1 in human uterine leiomyomata.人子宫平滑肌瘤中潜伏性转化生长因子β结合蛋白-1和原纤维蛋白-1表达增加。
Mol Hum Reprod. 2007 May;13(5):343-9. doi: 10.1093/molehr/gam007. Epub 2007 Mar 14.
5
The role of neutrophil elastase in elastin metabolism of pelvic tissues from women with stress urinary incontinence.中性粒细胞弹性蛋白酶在压力性尿失禁女性盆底组织弹性蛋白代谢中的作用
Neurourol Urodyn. 2007;26(2):274-9. doi: 10.1002/nau.20347.
6
Volume change of uterine myomas during pregnancy: do myomas really grow?子宫肌瘤在孕期的体积变化：肌瘤真的会生长吗？
J Minim Invasive Gynecol. 2006 Sep-Oct;13(5):386-90. doi: 10.1016/j.jmig.2006.04.003.
7
In vitro culture significantly alters gene expression profiles and reduces differences between myometrial and fibroid smooth muscle cells.体外培养显著改变基因表达谱，并减少子宫肌层和平滑肌瘤平滑肌细胞之间的差异。
Mol Hum Reprod. 2006 Mar;12(3):187-207. doi: 10.1093/molehr/gal018. Epub 2006 Mar 8.
8
Spatial differences in biologic activity of large uterine leiomyomata.大型子宫平滑肌瘤生物活性的空间差异。
Fertil Steril. 2006 Jan;85(1):179-87. doi: 10.1016/j.fertnstert.2005.07.1294.
9
Elastin metabolism in pelvic tissues: is it modulated by reproductive hormones?盆腔组织中的弹性蛋白代谢：它是否受生殖激素调节？
Am J Obstet Gynecol. 2005 May;192(5):1605-13. doi: 10.1016/j.ajog.2004.11.027.
10
Sex steroidal regulation of uterine leiomyoma growth and apoptosis.性激素对子宫平滑肌瘤生长和凋亡的调节作用。
Hum Reprod Update. 2004 May-Jun;10(3):207-20. doi: 10.1093/humupd/dmh019.
Zotero 插件