National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
Planta Med. 2011 Sep;77(13):1542-4. doi: 10.1055/s-0030-1270782. Epub 2011 Feb 21.
From the leaves and bark of Zanthoxylum monophyllum, a new lignan, 3-methoxy-3',4'-methylenedioxylignan-4,8,9,9'-tetraol (1), has been isolated along with 22 known compounds (2- 23), fifteen of them reported for the first time from Z. monophyllum. Their chemical structures were elucidated using detailed spectroscopic studies and chemical analysis. All compounds were evaluated for antimicrobial and antiprotozoal activities. Alkaloids BIS-[6-(5,6-dihydro-chelerythrinyl)] ether (2) and 6-ethoxy-chelerythrine (4) exhibited strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA). Compound 4-methoxy-N-methyl-2-quinolone (9) exhibited significant activity against MRSA (IC50 value of 8.0 µM) while compound 5,8,4'-trihydroxy-3,7,3'-trimethoxyflavone (10) showed weak activity against Plasmodium falciparum.
从两面针的叶子和树皮中，分离得到一个新的木脂素化合物 3-甲氧基-3',4'-亚甲基二氧木脂素-4,8,9,9'-四醇（1），此外还分离得到 22 种已知化合物（2-23），其中 15 种化合物为首次从两面针中分离得到。利用详细的光谱研究和化学分析阐明了它们的化学结构。所有化合物均进行了抗微生物和抗原生动物活性评价。生物碱 BIS-[6-(5,6-二氢-chelerethrylnyl)] 醚（2）和 6-乙氧基-chelerythrine（4）对烟曲霉和耐甲氧西林金黄色葡萄球菌（MRSA）表现出很强的活性。化合物 4-甲氧基-N-甲基-2-喹诺酮（9）对 MRSA 具有显著的活性（IC50 值为 8.0μM），而化合物 5,8,4'-三羟基-3,7,3'-三甲氧基黄酮（10）对疟原虫表现出较弱的活性。
