Ahsan Monira, Haque Mohammad Rashedul, Hossain Md Belayet, Islam Sheikh Nazrul, Gray Alexander I, Hasan Choudhury Mahmood
Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka 1000, Bangladesh.
Institute of Nutrition and Food Science, University of Dhaka, Dhaka 1000, Bangladesh.
Phytochemistry. 2014 Jul;103:8-12. doi: 10.1016/j.phytochem.2014.03.008. Epub 2014 Apr 22.
Four quinolone-terpene alkaloids, chelerybulgarine (1), 2'-episimulanoquinoline (3), 2,11-didemethoxyvepridimerine B (4), and rhetsidimerine (5) were isolated from the root bark of Zanthoxylum rhetsa DC. Chelerybulgarine (1) is a C-C linked terpene alkaloid where the C-6 of dihydrochelerythrine is linked to C-11 of the sesquiterpenoid 10β-methoxybulgarene. 2'-Episimulanoquinoline is a dimeric alkaloid containing dihydrochelerythrine and 8-methoxy-N-methylflindersine moieties, whereas 2,11-didemethoxyvepridimerine B and rhetsidimerine are dimeric prenylated quinolone alkaloids. Seven of the isolated compounds exhibited weak cytotoxicity when tested against a panel of six human stomach-cancer cell lines.
从刺花椒（Zanthoxylum rhetsa DC.）的根皮中分离出四种喹诺酮-萜类生物碱，即白屈菜红碱（1）、2'-表异西番莲喹啉（3）、2,11-二去甲氧基维普地米林B（4）和刺花椒二聚碱（5）。白屈菜红碱（1）是一种碳-碳连接的萜类生物碱，其中二氢白屈菜红碱的C-6与倍半萜10β-甲氧基保加烯的C-11相连。2'-表异西番莲喹啉是一种含有二氢白屈菜红碱和8-甲氧基-N-甲基弗林德辛部分的二聚生物碱，而2,11-二去甲氧基维普地米林B和刺花椒二聚碱是二聚的异戊烯基喹诺酮生物碱。在对六种人胃癌细胞系进行测试时，七种分离出的化合物表现出较弱的细胞毒性。
