Department of Medicine/Infectious Diseases, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA.
Expert Rev Anti Infect Ther. 2011 Feb;9(2):261-9. doi: 10.1586/eri.10.158.
Adenosine is an endogenous purine metabolite whose concentration in human blood plasma rises from nanomolar to micromolar concentrations during the inflammatory process. Leukocytes express seven-transmembrane adenosine receptors whose engagement modulates Toll-like receptor-mediated cytokine responses, in part via modulation of intracellular cyclic adenosine monophosphate. Adenosine analogs are used clinically to treat arrhythmias and apnea of prematurity. Herein, we consider the potential of adenosine analogs as innate immune response modifiers to prevent and/or treat infection.
腺苷是一种内源性嘌呤代谢物，其在人类血浆中的浓度在炎症过程中从纳摩尔上升到微摩尔。白细胞表达七跨膜腺苷受体，其参与调节 Toll 样受体介导的细胞因子反应，部分通过调节细胞内环磷酸腺苷。腺苷类似物临床上用于治疗心律失常和早产儿呼吸暂停。在此，我们考虑将腺苷类似物作为先天免疫反应调节剂用于预防和/或治疗感染的潜力。
