Jin Yan-Yan, Liang Li, Fu Jun-Fen, Wang Xiu-Min
Department of Endocrinology, Children's Hospital Affiliated to Medical School of Zhejiang University, Hangzhou 310003, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2011 Feb;13(2):138-40.
To investigate the incident and prevalence of type 2 diabetes mellitus (T2DM) and prediabetes in obese children in the last ten years.
The clinical data of hospitalized children with newly diagnosed diabetes mellitus (DM) or obesity between October 2000 and September 2011 were retrospectively studied.
A total of 503 newly onset cases were diagnosed as DM in the past ten years, of which 31 were diagnosed as T2DM. The prevalence of T2DM in the second five-year duration increased significantly compared with that in the first five-year duration (0.18‰ vs 0.05‰; P<0.01). The number of cases of type 1 diabetes mellitus (T1DM) and T2DM increased by 1.35 fold and 4.20 fold, respectively in the second five-year duration. A total of 1301 obese patients received oral glucose tolerance tests, and 29 cases were diagnosed with T2DM and 255 cases with prediabetes. Of the 255 cases of prediabetes, 133 had dyslipidemia, 138 had non-alcoholic fatty liver disease and 53 had hypertension.
The prevalence rates of T1DM and T2DM increased significantly in the last 5 years. The prevalence of T2DM increased more significantly than T1DM. There was a higher prevalence of prediabetes in obese children. Childhood obesity predicts a higher risk of T2DM and cardiovascular disease in the future.
调查过去十年肥胖儿童2型糖尿病（T2DM）和糖尿病前期的发病率及患病率。
回顾性研究2000年10月至2011年9月期间新诊断为糖尿病（DM）或肥胖的住院儿童的临床资料。
在过去十年中，共诊断出503例新发病例为DM，其中31例被诊断为T2DM。T2DM在第二个五年期的患病率与第一个五年期相比显著增加（0.18‰对0.05‰；P<0.01）。在第二个五年期，1型糖尿病（T1DM）和T2DM的病例数分别增加了1.35倍和4.20倍。共有1301例肥胖患者接受了口服葡萄糖耐量试验，其中29例被诊断为T2DM，255例被诊断为糖尿病前期。在255例糖尿病前期患者中，133例患有血脂异常，138例患有非酒精性脂肪性肝病，53例患有高血压。
在过去5年中，T1DM和T2DM的患病率显著增加。T2DM的患病率比T1DM增加得更显著。肥胖儿童中糖尿病前期的患病率较高。儿童肥胖预示着未来患T2DM和心血管疾病的风险更高。
