体外检测柠檬酸杆菌素（CEM-102，fusidic acid sodium）对囊性纤维化患者分离的金黄色葡萄球菌的活性及其对妥布霉素和阿米卡星对铜绿假单胞菌和洋葱伯克霍尔德菌活性的影响。
In vitro activity of fusidic acid (CEM-102, sodium fusidate) against Staphylococcus aureus isolates from cystic fibrosis patients and its effect on the activities of tobramycin and amikacin against Pseudomonas aeruginosa and Burkholderia cepacia.
机构信息
Department of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA.
出版信息
Antimicrob Agents Chemother. 2011 May;55(5):2417-9. doi: 10.1128/AAC.01672-10. Epub 2011 Feb 22.
Abstract
We tested the MICs of fusidic acid (CEM-102) plus other agents against 40 methicillin-resistant Staphylococcus aureus (MRSA) isolates from cystic fibrosis patients and the activities of fusidic acid with or without tobramycin or amikacin against Pseudomonas aeruginosa, MRSA, and Burkholderia cepacia isolates from cystic fibrosis patients in a 24-h time-kill study. Fusidic acid was potent (MICs, 0.125 to 0.5 μg/ml; a single 500-mg dose of fusidic acid at 8 h averaged 8 to 12. 5 μg/ml with 91 to 97% protein binding) against all MRSA strains. No antagonism was observed; synergy occurred for one MRSA strain treated with fusidic acid plus tobramycin.
摘要
我们测试了 CEM-102（夫西地酸）联合其他药物对 40 株来自囊性纤维化患者的耐甲氧西林金黄色葡萄球菌（MRSA）的最小抑菌浓度（MICs），并在 24 小时时间杀伤研究中检测了夫西地酸联合妥布霉素或阿米卡星对来自囊性纤维化患者的铜绿假单胞菌、MRSA 和洋葱伯克霍尔德菌的活性。夫西地酸对所有 MRSA 菌株均具有强大的作用（MICs，0.125 至 0.5 μg/ml；单次给予 500mg 夫西地酸，在 8 小时时平均达到 8 至 12.5 μg/ml，与 91 至 97%的蛋白结合）。未观察到拮抗作用；在联合妥布霉素治疗一株 MRSA 时出现协同作用。
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