替考拉宁单独及联合用药时的时间杀菌试验的抗葡萄球菌活性。
Antistaphylococcal activities of telavancin tested alone and in combination by time-kill assay.
机构信息
Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA.
出版信息
Antimicrob Agents Chemother. 2010 May;54(5):2201-5. doi: 10.1128/AAC.01143-09. Epub 2010 Feb 16.
Abstract
Synergy time-kill studies against 40 methicillin-resistant Staphylococcus aureus (MRSA) strains of differing resistance phenotypes were conducted. Subinhibitory concentrations of telavancin were combined with sub-MIC concentrations of other antimicrobial agents that might be used in combination with telavancin to provide Gram-negative coverage. The highest incidence of synergy was found after 24 h with gentamicin (90% of strains), followed by ceftriaxone (88%), rifampin and meropenem (each 65%), cefepime (45%), and ciprofloxacin (38%) for combinations tested at or below the intermediate breakpoint for each agent.
摘要
对 40 株不同耐药表型的耐甲氧西林金黄色葡萄球菌（MRSA）菌株进行协同时间杀伤研究。替考拉宁的亚抑菌浓度与其他抗菌药物的亚 MIC 浓度联合使用，这些药物可能与替考拉宁联合使用以提供革兰氏阴性菌覆盖。在 24 小时后，与氨基糖苷类药物（90%的菌株）、头孢曲松（88%）、利福平、美罗培南（各 65%）、头孢吡肟（45%）和环丙沙星（38%）联合使用时，协同作用的发生率最高，这些组合均低于每种药物的中介折点。
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