Department of Radiology, Kinki University Faculty of Medicine, Osaka, [corrected] Japan.
Invest Radiol. 2011 Apr;46(4):277-83. doi: 10.1097/RLI.0b013e318200f67d.
To investigate the ability of T1 mapping of liver on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging for the estimation of liver function.
Local institutional review board approved this study. Ninety-one patients (64 men, 27 women; mean age, 67.4 years) were classified into 4 groups as follows: normal liver function (NLF), n = 16; chronic hepatitis (CH), n = 38; liver cirrhosis with Child-Pugh A (LCA), n = 20; and liver cirrhosis with Child-Pugh B (LCB), n = 17. Look-Locker sequences (single slice multiphase imaging using gradient-echo sequence with inversion recovery pulse) were obtained before and at 3, 8, 13, and 18 minutes after Gd-EOB-DTPA administration. T1 mapping of liver parenchyma was calculated from the Look-Locker sequence. T1 relaxation time of liver and reduction rate of T1 relaxation time between pre- and postcontrast enhancement were measured. The Bonferroni t test was used for comparisons between the 4 groups.
Precontrast T1 relaxation times were significantly longer for LCA and LCB than for NLF, and that of LCB was longer than that of chronic hepatitis (P < 0.05). Postcontrast T1 relaxation times were significantly longer for LCB than for other groups at all time points. Those of LCA were longer than those of NLF at all time points. Reduction rates were significantly lower for LCB than for the other groups at ≥8 minutes.
Evaluation of hepatic uptake of Gd-EOB-DTPA using T1 mapping of liver parenchyma can help estimate liver function.
研究钆塞酸二钠（Gd-EOB-DTPA）增强磁共振成像肝脏 T1 mapping 对肝功能的评估能力。
本研究经当地机构审查委员会批准。91 例患者（64 例男性，27 例女性；平均年龄 67.4 岁）分为 4 组：正常肝功能（NLF）组 16 例，慢性肝炎（CH）组 38 例，Child-Pugh A 级肝硬化（LCA）组 20 例，Child-Pugh B 级肝硬化（LCB）组 17 例。在 Gd-EOB-DTPA 给药前和给药后 3、8、13 和 18 分钟，使用梯度回波序列的反转恢复脉冲进行 Look-Locker 序列（单层面多相位成像）扫描。从 Look-Locker 序列计算肝脏实质的 T1 mapping。测量肝脏 T1 弛豫时间和增强前后 T1 弛豫时间的降低率。采用 Bonferroni t 检验比较 4 组间差异。
LCA 和 LCB 组的预对比 T1 弛豫时间明显长于 NLF 组，而 LCB 组的 T1 弛豫时间长于 CH 组（P<0.05）。LCB 组各时间点的 postcontrast T1 弛豫时间均明显长于其他组。LCA 组各时间点的 T1 弛豫时间均长于 NLF 组。LCB 组在≥8 分钟时的 T1 弛豫时间降低率明显低于其他组。
使用肝脏实质 T1 mapping 评估 Gd-EOB-DTPA 的肝摄取可以帮助评估肝功能。
