Wheeldon Ian, Ahari Amirhossein F, Khademhosseini Ali
Department of Medicine, Center for Biomedical Engineering, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA and Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
JALA Charlottesv Va. 2010 Dec 1;15(6):440-448. doi: 10.1016/j.jala.2010.05.003.
The integration of microfabrication technologies with advanced biomaterials has led to the development of powerful tools to control the cellular microenvironment and the microarchitecture of engineered tissue constructs. Here we review this area, with a focus on the work accomplished in our laboratory. In particular, we discuss techniques to develop hydrogel microstructures for controlling cell aggregate formation to regulate stem cell behavior as well as a bottom-up and a top-down microengineering approach to creating biomimic tissue-like structures.
微制造技术与先进生物材料的结合，催生了用于控制细胞微环境和工程组织构建体微结构的强大工具。在此，我们回顾这一领域，重点关注我们实验室所取得的工作成果。特别地，我们讨论了开发水凝胶微结构以控制细胞聚集体形成从而调节干细胞行为的技术，以及创建仿生组织样结构的自下而上和自上而下的微工程方法。
