• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

基于图像的特定患者心室模型，具有用于心功能评估和手术设计优化的流固耦合作用

Image-Based Patient-Specific Ventricle Models with Fluid-Structure Interaction for Cardiac Function Assessment and Surgical Design Optimization.

作者信息

Tang Dalin, Yang Chun, Geva Tal, Del Nido Pedro J

机构信息

Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609.

出版信息

Prog Pediatr Cardiol. 2010 Dec 1;30(1-2):51-62. doi: 10.1016/j.ppedcard.2010.09.007.

DOI:10.1016/j.ppedcard.2010.09.007
PMID:21344066
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3041970/
Abstract

Recent advances in medical imaging technology and computational modeling techniques are making it possible that patient-specific computational ventricle models be constructed and used to test surgical hypotheses and replace empirical and often risky clinical experimentation to examine the efficiency and suitability of various reconstructive procedures in diseased hearts. In this paper, we provide a brief review on recent development in ventricle modeling and its potential application in surgical planning and management of tetralogy of Fallot (ToF) patients. Aspects of data acquisition, model selection and construction, tissue material properties, ventricle layer structure and tissue fiber orientations, pressure condition, model validation and virtual surgery procedures (changing patient-specific ventricle data and perform computer simulation) were reviewed. Results from a case study using patient-specific cardiac magnetic resonance (CMR) imaging and right/left ventricle and patch (RV/LV/Patch) combination model with fluid-structure interactions (FSI) were reported. The models were used to evaluate and optimize human pulmonary valve replacement/insertion (PVR) surgical procedure and patch design and test a surgical hypothesis that PVR with small patch and aggressive scar tissue trimming in PVR surgery may lead to improved recovery of RV function and reduced stress/strain conditions in the patch area.

摘要

医学成像技术和计算建模技术的最新进展使得构建患者特异性的计算心室模型成为可能，这些模型可用于检验手术假设，并取代经验性且通常具有风险的临床实验，以研究各种心脏疾病重建手术的效率和适用性。在本文中，我们简要回顾了心室建模的最新进展及其在法洛四联症（ToF）患者手术规划和管理中的潜在应用。我们回顾了数据采集、模型选择与构建、组织材料特性、心室层结构和组织纤维方向、压力条件、模型验证以及虚拟手术程序（更改患者特异性心室数据并进行计算机模拟）等方面。报告了一项使用患者特异性心脏磁共振（CMR）成像以及具有流固相互作用（FSI）的右/左心室与补片（RV/LV/Patch）组合模型的案例研究结果。这些模型用于评估和优化人类肺动脉瓣置换/植入（PVR）手术程序和补片设计，并检验一个手术假设，即在PVR手术中使用小补片并积极修剪瘢痕组织可能会改善右心室功能恢复，并降低补片区域的应力/应变情况。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/329a0b06b9ae/nihms239658f16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/3700f8705367/nihms239658f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/8aec076f2811/nihms239658f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/4b8fd21650f8/nihms239658f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/8a339cbfaccf/nihms239658f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/3ffa6704cdf2/nihms239658f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/b17a0e4eff27/nihms239658f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/c06de0bc0ac8/nihms239658f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/4a6f70c977c5/nihms239658f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/d781d0e2c8c3/nihms239658f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/43774250beb8/nihms239658f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/3501598d64ba/nihms239658f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/9b440cb14876/nihms239658f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/cd8476667b04/nihms239658f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/00f11ec4d515/nihms239658f14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/ec3aa765456b/nihms239658f15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/329a0b06b9ae/nihms239658f16.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/3700f8705367/nihms239658f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/8aec076f2811/nihms239658f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/4b8fd21650f8/nihms239658f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/8a339cbfaccf/nihms239658f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/3ffa6704cdf2/nihms239658f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/b17a0e4eff27/nihms239658f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/c06de0bc0ac8/nihms239658f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/4a6f70c977c5/nihms239658f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/d781d0e2c8c3/nihms239658f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/43774250beb8/nihms239658f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/3501598d64ba/nihms239658f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/9b440cb14876/nihms239658f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/cd8476667b04/nihms239658f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/00f11ec4d515/nihms239658f14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/ec3aa765456b/nihms239658f15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8005/3041970/329a0b06b9ae/nihms239658f16.jpg

相似文献

1
Image-Based Patient-Specific Ventricle Models with Fluid-Structure Interaction for Cardiac Function Assessment and Surgical Design Optimization.基于图像的特定患者心室模型，具有用于心功能评估和手术设计优化的流固耦合作用
Prog Pediatr Cardiol. 2010 Dec 1;30(1-2):51-62. doi: 10.1016/j.ppedcard.2010.09.007.
2
Patient-specific MRI-based 3D FSI RV/LV/patch models for pulmonary valve replacement surgery and patch optimization.基于患者特异性MRI的三维流体结构相互作用右心室/左心室/补片模型用于肺动脉瓣置换手术及补片优化。
J Biomech Eng. 2008 Aug;130(4):041010. doi: 10.1115/1.2913339.
3
Two-layer passive/active anisotropic FSI models with fiber orientation: MRI-based patient-specific modeling of right ventricular response to pulmonary valve insertion surgery.具有纤维取向的两层被动/主动各向异性流固耦合模型：基于MRI的肺动脉瓣植入手术右心室反应的患者特异性建模。
Mol Cell Biomech. 2007 Sep;4(3):159-76.
4
In vivo MRI-Based 3D FSI RV/LV Models for Human Right Ventricle and Patch Design for Potential Computer-Aided Surgery Optimization.基于体内磁共振成像的用于人类右心室的三维流体结构相互作用右心室/左心室模型及用于潜在计算机辅助手术优化的补片设计
Comput Struct. 2007;85(11-14):988-997. doi: 10.1016/j.compstruc.2006.11.008.
5
Multi-Band Surgery for Repaired Tetralogy of Fallot Patients With Reduced Right Ventricle Ejection Fraction: A Pilot Study.右心室射血分数降低的法洛四联症修复患者的多频段手术：一项初步研究。
Front Physiol. 2020 Mar 19;11:198. doi: 10.3389/fphys.2020.00198. eCollection 2020.
6
Using contracting band to improve right ventricle ejection fraction for patients with repaired tetralogy of Fallot: a modeling study using patient-specific CMR-based 2-layer anisotropic models of human right and left ventricles.采用收缩带提高法洛四联症修复术后患者右心室射血分数：基于患者特定的心脏磁共振成像的 2 层各向异性模型的建模研究。
J Thorac Cardiovasc Surg. 2013 Jan;145(1):285-93, 293.e1-2. doi: 10.1016/j.jtcvs.2012.03.009. Epub 2012 Apr 7.
7
A Novel Pulmonary Valve Replacement Surgery Strategy Using Contracting Band for Patients With Repaired Tetralogy of Fallot: An MRI-Based Multipatient Modeling Study.一种用于法洛四联症修复术后患者的使用收缩带的新型肺动脉瓣置换手术策略：一项基于MRI的多患者建模研究。
Front Bioeng Biotechnol. 2021 May 19;9:638934. doi: 10.3389/fbioe.2021.638934. eCollection 2021.
8
Patient-Specific MRI-Based Right Ventricle Models Using Different Zero-Load Diastole and Systole Geometries for Better Cardiac Stress and Strain Calculations and Pulmonary Valve Replacement Surgical Outcome Predictions.基于患者特异性MRI的右心室模型，使用不同的零负荷舒张期和收缩期几何形状，以更好地进行心脏应力和应变计算以及肺动脉瓣置换手术结果预测。
PLoS One. 2016 Sep 14;11(9):e0162986. doi: 10.1371/journal.pone.0162986. eCollection 2016.
9
Long-term follow-up in repaired tetralogy of fallot: can deformation imaging help identify optimal timing of pulmonary valve replacement?法洛四联症修复术后的长期随访：应变成像能否帮助确定肺动脉瓣置换的最佳时机？
J Am Soc Echocardiogr. 2014 Dec;27(12):1305-10. doi: 10.1016/j.echo.2014.09.012. Epub 2014 Oct 18.
10
Impact of surgical pulmonary valve replacement on ventricular strain and synchrony in patients with repaired tetralogy of Fallot: a cardiovascular magnetic resonance feature tracking study.外科肺动脉瓣置换术对法洛四联症修复患者心室应变和同步性的影响：一项心血管磁共振特征追踪研究。
J Cardiovasc Magn Reson. 2018 Jun 18;20(1):37. doi: 10.1186/s12968-018-0460-0.

引用本文的文献

1
Accurate Reconstruction of Right Heart Shape and Motion From Cine-MRI for Image-Driven Computational Hemodynamics.基于电影磁共振成像精确重建右心形状与运动以用于图像驱动的计算血流动力学
Int J Numer Method Biomed Eng. 2025 Jan;41(1):e3891. doi: 10.1002/cnm.3891.
2
Current progress toward isogeometric modeling of the heart biophysics.心脏生物物理学等几何建模的当前进展。
Biophys Rev (Melville). 2023 Nov 13;4(4):041301. doi: 10.1063/5.0152690. eCollection 2023 Dec.
3
A Comparison of Vessel Patch Materials in Tetralogy of Fallot Patients Using Virtual Surgery Techniques.

本文引用的文献

1
First finite element model of the left ventricle with mitral valve: insights into ischemic mitral regurgitation.左心室与二尖瓣的首个有限元模型：对缺血性二尖瓣反流的深入了解。
Ann Thorac Surg. 2010 May;89(5):1546-53. doi: 10.1016/j.athoracsur.2010.02.036.
2
In vivo MRI-Based 3D FSI RV/LV Models for Human Right Ventricle and Patch Design for Potential Computer-Aided Surgery Optimization.基于体内磁共振成像的用于人类右心室的三维流体结构相互作用右心室/左心室模型及用于潜在计算机辅助手术优化的补片设计
Comput Struct. 2007;85(11-14):988-997. doi: 10.1016/j.compstruc.2006.11.008.
3
Patient-specific MRI-based 3D FSI RV/LV/patch models for pulmonary valve replacement surgery and patch optimization.
运用虚拟手术技术比较法洛四联症患者的血管补片材料。
Ann Biomed Eng. 2023 Jul;51(7):1420-1435. doi: 10.1007/s10439-023-03144-x. Epub 2023 Feb 1.
4
Optimization of Left Ventricle Pace Maker Location Using Echo-Based Fluid-Structure Interaction Models.使用基于超声心动图的流固耦合模型优化左心室起搏器位置
Front Physiol. 2022 Feb 17;13:843421. doi: 10.3389/fphys.2022.843421. eCollection 2022.
5
Numerical Simulation Study on the Mechanism of Formation of Apical Aneurysm in Hypertrophic Cardiomyopathy With Midventricular Obstruction.肥厚型心肌病伴心室中部梗阻时心尖部动脉瘤形成机制的数值模拟研究
Front Physiol. 2021 Jul 21;12:717717. doi: 10.3389/fphys.2021.717717. eCollection 2021.
6
Personalized intervention cardiology with transcatheter aortic valve replacement made possible with a non-invasive monitoring and diagnostic framework.经导管主动脉瓣置换术的个性化介入心脏病学，可通过非侵入性监测和诊断框架实现。
Sci Rep. 2021 May 25;11(1):10888. doi: 10.1038/s41598-021-85500-2.
7
An Introductory Overview of Image-Based Computational Modeling in Personalized Cardiovascular Medicine.个性化心血管医学中基于图像的计算建模简介
Front Bioeng Biotechnol. 2020 Sep 25;8:529365. doi: 10.3389/fbioe.2020.529365. eCollection 2020.
8
Comparison of Right Ventricle Morphological and Mechanical Characteristics for Healthy and Patients with Tetralogy of Fallot: An In Vivo MRI-Based Modeling Study.健康人与法洛四联症患者右心室形态学和力学特征的比较：一项基于体内磁共振成像的建模研究。
Mol Cell Biomech. 2017;14(3):137-151. doi: 10.3970/mcb.2017.014.137.
9
Towards a Computational Framework for Modeling the Impact of Aortic Coarctations Upon Left Ventricular Load.建立一个用于模拟主动脉缩窄对左心室负荷影响的计算框架。
Front Physiol. 2018 May 28;9:538. doi: 10.3389/fphys.2018.00538. eCollection 2018.
10
In vivo estimation of passive biomechanical properties of human myocardium.人体心肌被动生物力学特性的体内评估。
Med Biol Eng Comput. 2018 Sep;56(9):1615-1631. doi: 10.1007/s11517-017-1768-x. Epub 2018 Feb 26.
基于患者特异性MRI的三维流体结构相互作用右心室/左心室/补片模型用于肺动脉瓣置换手术及补片优化。
J Biomech Eng. 2008 Aug;130(4):041010. doi: 10.1115/1.2913339.
4
Subject-specific computational simulation of left ventricular flow based on magnetic resonance imaging.基于磁共振成像的左心室血流特定对象计算模拟
Proc Inst Mech Eng H. 2008 May;222(4):475-85. doi: 10.1243/09544119JEIM310.
5
Two-layer passive/active anisotropic FSI models with fiber orientation: MRI-based patient-specific modeling of right ventricular response to pulmonary valve insertion surgery.具有纤维取向的两层被动/主动各向异性流固耦合模型：基于MRI的肺动脉瓣植入手术右心室反应的患者特异性建模。
Mol Cell Biomech. 2007 Sep;4(3):159-76.
6
Surgical management of right ventricular dysfunction late after repair of tetralogy of fallot: right ventricular remodeling surgery.法洛四联症修复术后晚期右心室功能障碍的外科治疗：右心室重塑手术
Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2006:29-34. doi: 10.1053/j.pcsu.2006.02.007.
7
Recommendations of the National Heart, Lung, and Blood Institute Working Group on Future Direction in Cardiac Surgery.美国国立心肺血液研究所心脏外科未来发展方向工作组的建议
Circulation. 2005 Jun 7;111(22):3007-13. doi: 10.1161/CIRCULATIONAHA.104.530154.
8
Effect of ventricular size and patch stiffness in surgical anterior ventricular restoration: a finite element model study.心室大小和补片硬度在手术前心室修复中的作用：一项有限元模型研究。
Ann Thorac Surg. 2005 Jan;79(1):185-93. doi: 10.1016/j.athoracsur.2004.06.007.
9
Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension.右心室压力-容积环的磁共振成像分析：在肺动脉高压患者中的体内验证及临床应用
Circulation. 2004 Oct 5;110(14):2010-6. doi: 10.1161/01.CIR.0000143138.02493.DD. Epub 2004 Sep 27.
10
Factors associated with impaired clinical status in long-term survivors of tetralogy of Fallot repair evaluated by magnetic resonance imaging.通过磁共振成像评估法洛四联症修复术后长期存活者临床状态受损的相关因素。
J Am Coll Cardiol. 2004 Mar 17;43(6):1068-74. doi: 10.1016/j.jacc.2003.10.045.