Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital at Taipei, Taiwan.
Reprod Sci. 2012 May;19(5):505-12. doi: 10.1177/1933719111426601. Epub 2012 Feb 16.
To investigate the association between maternal oxidative stress at mid-gestation and subsequent development of pregnancy complications.
A total of 503 healthy pregnant women provided their blood and urine samples at 24 to 26 weeks of gestation and were prospectively followed through postpartum. These samples were used to assess a variety of oxidative stress markers, including plasma total antioxidant capacity, 8-isoprostane, erythrocyte glutathione peroxidase and superoxide dismutase activity, and urinary 8-hydroxydeoxyguanosine (8-OHdG).
Compared with women with uncomplicated pregnancies, significantly higher plasma 8-isoprostane levels were noted in women who developed preeclampsia (P = .008) and small-for-gestational age infants (P = .002), while higher urinary 8-OHdG concentrations were noted in women who subsequently had low-birth-weight neonates (<2500 g, P = .043).
Increased maternal oxidative stress at mid-gestation was associated with subsequent pregnancy complications.
探讨妊娠中期母体氧化应激与随后发生妊娠并发症的关系。
共纳入 503 名健康孕妇，在妊娠 24 至 26 周时采集其血样和尿样，并进行前瞻性随访至产后。这些样本用于评估多种氧化应激标志物，包括血浆总抗氧化能力、8-异前列腺素、红细胞谷胱甘肽过氧化物酶和超氧化物歧化酶活性以及尿 8-羟基脱氧鸟苷（8-OHdG）。
与无并发症妊娠的孕妇相比，发生子痫前期（P =.008）和胎儿小于胎龄（P =.002）的孕妇血浆 8-异前列腺素水平显著升高，而随后出生低体重儿（<2500g，P =.043）的孕妇尿 8-OHdG 浓度较高。
妊娠中期母体氧化应激增加与随后发生的妊娠并发症有关。
