不完全厌氧作为甲硝唑“耐药性”的一个原因。

Incomplete anaerobiosis as a cause of metronidazole 'resistance'.

作者信息

Milne S E, Stokes E J, Waterworth P M

出版信息

J Clin Pathol. 1978 Oct;31(10):933-5. doi: 10.1136/jcp.31.10.933.

DOI:10.1136/jcp.31.10.933

PMID:213449

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1145454/

Abstract

Clostridium welchii, used as a control, was found to grow well in a microaerophilic jar used for campylobacters but appeared resistant to a metronidazole disc although the campylobacter was sensitive. Minimum inhibitory concentrations for six strains of Cl. welchii were up to 64-fold higher in these conditions than when grown anaerobically. Zones of inhibition with both Cl. welchii and Bacteroides fragilis varied with the amount of air admitted to anaerobic jars.

摘要

作为对照的韦氏梭菌，发现在用于弯曲杆菌的微需氧罐中生长良好，但尽管弯曲杆菌对甲硝唑纸片敏感，它却似乎对其耐药。在这些条件下，六株韦氏梭菌的最低抑菌浓度比在厌氧条件下生长时高出多达64倍。韦氏梭菌和脆弱拟杆菌的抑菌圈会随着进入厌氧罐的空气量而变化。