D'Argenio D Z
Department of Biomedical Engineering, University of Southern California, Los Angeles 90089-1451.
Math Biosci. 1990 Apr;99(1):105-18. doi: 10.1016/0025-5564(90)90141-k.
An experiment design procedure is proposed for nonlinear parameter estimation studies that formally incorporates prior parameter uncertainty. The design criterion derives from information theory considerations and involves an asymptotic interpretation of the expected posterior information provided by an experiment. A pharmacokinetic sample schedule design problem is used to illustrate and evaluate this information theoretic design strategy. The model considered is commonly used to describe the plasma concentration of a drug following its oral administration. The limitations and advantages of the proposed design procedure are discussed in relation to other previously reported design techniques for incorporating parameter uncertainty.
针对正式纳入先验参数不确定性的非线性参数估计研究，提出了一种实验设计程序。该设计准则源于信息论考量，涉及对实验提供的预期后验信息的渐近解释。一个药代动力学样本调度设计问题被用于说明和评估这种信息论设计策略。所考虑的模型通常用于描述药物口服后的血浆浓度。结合其他先前报道的纳入参数不确定性的设计技术，讨论了所提出设计程序的局限性和优点。
