Hashimoto Y, Miura S, Degawa M
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Princess Takamatsu Symp. 1990;21:129-36.
Carcinogenic aromatic amines such as amino acid and protein pyrolysate compounds and aminoazo dyes induced predominantly P450IA2, which is responsible for mutagenic activation of the aromatic amines, in rats and mice. The induction rate and total activity of this cytochrome P-450 isozyme were well correlated with sex, species, and target organ differences in hepatocarcinogenic susceptibility of animals to the aromatic amines. Preneoplastic liver cells induced by treatment with N,N-diethylnitrosamine and 2-acetylaminofluorene diminished the capacity for P450IA2 induction but retained that for P450IA1 induction. These findings confirm that P450IA2 has an important role in hepatocarcinogenesis by aromatic amines.
致癌性芳香胺，如氨基酸和蛋白质热解产物化合物以及氨基偶氮染料，在大鼠和小鼠中主要诱导P450IA2，该酶负责芳香胺的诱变活化。这种细胞色素P-450同工酶的诱导率和总活性与动物对芳香胺的肝癌致癌易感性中的性别、物种和靶器官差异密切相关。用N，N-二乙基亚硝胺和2-乙酰氨基芴处理诱导的癌前肝细胞降低了P450IA2的诱导能力，但保留了P450IA1的诱导能力。这些发现证实P450IA2在芳香胺诱导的肝癌发生中起重要作用。
