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1
Species difference among experimental rodents in the activity and induction of cytochrome P-450 isozymes for mutagenic activation of carcinogenic aromatic amines.实验啮齿动物在细胞色素P - 450同工酶的活性及诱导方面的种属差异，这些同工酶参与致癌性芳香胺的诱变活化。
Jpn J Cancer Res. 1990 Dec;81(12):1253-8. doi: 10.1111/j.1349-7006.1990.tb02687.x.
2
Organ selective induction of cytochrome P-448 isozymes in the rat by 2-methoxy-4-aminoazobenzene and 3-methylcholanthrene.2-甲氧基-4-氨基偶氮苯和3-甲基胆蒽对大鼠细胞色素P-448同工酶的器官选择性诱导作用。
J Biochem. 1987 Jun;101(6):1437-45. doi: 10.1093/oxfordjournals.jbchem.a122013.
3
3-Methoxy-4-aminoazobenzene, a unique carcinogenic aromatic amine as a substrate for cytochrome-P-450-mediated mutagenesis.
Mutat Res. 1985 Nov-Dec;152(2-3):125-9. doi: 10.1016/0027-5107(85)90054-5.
4
Renal and hepatic microsomal enzymes responsible for bioactivation of 3-methoxy-4-aminoazobenzene in the rodent.
Biochem Pharmacol. 1991 Oct 9;42(9):1655-9. doi: 10.1016/0006-2952(91)90499-u.
5
Hepatocarcinogenic heterocyclic aromatic amines that induce cytochrome P-448 isozymes, mainly cytochrome P-448H (P-450IA2), responsible for mutagenic activation of the carcinogens in rat liver.诱导细胞色素P-448同工酶（主要是细胞色素P-448H，即P-450IA2）的肝癌致癌性杂环胺，该同工酶负责大鼠肝脏中致癌物的诱变激活。
Carcinogenesis. 1989 Jun;10(6):1119-22. doi: 10.1093/carcin/10.6.1119.
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3-Methoxy-4-aminoazobenzene, a selective inducer for a high spin form of cytochrome P-448 in rat liver microsomes.3-甲氧基-4-氨基偶氮苯，大鼠肝微粒体中细胞色素P-448高自旋形式的选择性诱导剂。
Biochem Biophys Res Commun. 1985 Dec 31;133(3):1072-7. doi: 10.1016/0006-291x(85)91245-8.
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Expression and induction of cytochrome P450 isozymes in hyperplastic nodules of rat liver.大鼠肝脏增生性结节中细胞色素P450同工酶的表达与诱导
Carcinogenesis. 1991 Nov;12(11):2151-6. doi: 10.1093/carcin/12.11.2151.
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Changes in the quantity and activity of cytochrome P-450 isozymes in primary cultured rat hepatocytes.原代培养大鼠肝细胞中细胞色素P-450同工酶的数量和活性变化
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Co-induction of cytochrome P-450 isozymes in rat liver by 2,4,5,2',4',5'-hexachlorobiphenyl or 3-methoxy-4-aminoazobenzene.2,4,5,2',4',5'-六氯联苯或3-甲氧基-4-氨基偶氮苯对大鼠肝脏细胞色素P-450同工酶的共诱导作用。
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Induction of cytochrome P-448 isozyme(s) in primary cultured rat hepatocytes by drugs which induce different isozymes in vivo.体内诱导不同同工酶的药物对原代培养大鼠肝细胞中细胞色素P - 448同工酶的诱导作用。
Biochem Biophys Res Commun. 1987 Nov 13;148(3):947-53. doi: 10.1016/s0006-291x(87)80224-3.

引用本文的文献

1
Species difference among experimental rodents in induction of P450IA family enzymes by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.2-氨基-1-甲基-6-苯基咪唑并[4,5-b]吡啶诱导实验啮齿动物P450IA家族酶的种属差异。
Jpn J Cancer Res. 1992 Oct;83(10):1047-51. doi: 10.1111/j.1349-7006.1992.tb02720.x.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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2
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.肝微粒体的一氧化碳结合色素。I. 其血红蛋白性质的证据。
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Further studies on the carcinogenicity of dyes related to 4-dimethylaminoazobenzene; the requirement for an unsubstituted 2-position.关于与4-二甲基氨基偶氮苯相关染料致癌性的进一步研究；2-位未取代的要求。
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Induction of carcinogen activation enzyme(s) by feeding of a carcinogenic tryptophan pyrolysate correlates to sex difference in the carcinogenesis of the mouse.通过喂食致癌性色氨酸裂解产物诱导致癌物激活酶与小鼠致癌作用中的性别差异相关。
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Species difference between rats and mice in activities of enzymes activating aromatic amines: effect of dietary 3-methoxy-4-aminoazobenzene.大鼠和小鼠在激活芳香胺的酶活性方面的种属差异：膳食3-甲氧基-4-氨基偶氮苯的影响。
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A high-spin form of cytochrome P-450 highly purified from polychlorinated biphenyl-treated rats. Catalytic characterization and immunochemical quantitation in liver microsomes.
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Purification and characterization of three forms of microsomal cytochrome P-450 in liver from 3-methylcholanthrene-treated guinea pigs.从经3-甲基胆蒽处理的豚鼠肝脏中纯化和鉴定三种形式的微粒体细胞色素P-450
Mol Pharmacol. 1983 Jan;23(1):258-64.
9
3-Methoxy-4-aminoazobenzene, a selective inducer for a high spin form of cytochrome P-448 in rat liver microsomes.3-甲氧基-4-氨基偶氮苯，大鼠肝微粒体中细胞色素P-448高自旋形式的选择性诱导剂。
Biochem Biophys Res Commun. 1985 Dec 31;133(3):1072-7. doi: 10.1016/0006-291x(85)91245-8.
10
Sex-dependent induction of hepatic enzymes for mutagenic activation of a tryptophan pyrolysate component, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]-indole, by feeding in mice.
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实验啮齿动物在细胞色素P - 450同工酶的活性及诱导方面的种属差异，这些同工酶参与致癌性芳香胺的诱变活化。

Species difference among experimental rodents in the activity and induction of cytochrome P-450 isozymes for mutagenic activation of carcinogenic aromatic amines.

作者信息

Degawa M, Agatsuma T, Hashimoto Y

机构信息

Department of Hygienic Chemistry, Tohoku University, Sendai.

出版信息

Jpn J Cancer Res. 1990 Dec;81(12):1253-8. doi: 10.1111/j.1349-7006.1990.tb02687.x.

DOI:10.1111/j.1349-7006.1990.tb02687.x
PMID:2125995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5918006/
Abstract

The expressions of hepatic microsomal cytochrome P-450 isozymes in male rats, mice, hamsters and guinea pigs were studied comparatively with or without an ip injection of a cytochrome P-450 inducer. The activity and quantity of microsomal cytochrome P-450 isozymes were determined respectively by a bacterial mutation assay with Salmonella typhimurium TA98 and immunochemical assays using monoclonal antibodies against rat cytochrome P-450 isozymes. 3-Methoxy-4-aminoazobenzene (3-MeO-AAB), 2-amino-3-methyl-9H-pyrido[2,3-b]indole acetate (MeA alpha C) and 3-methylcholanthrene were used as cytochrome P-450 inducers, and 7 carcinogenic aromatic amines including 3-MeO-AAB and MeA alpha C were used as substrates for the mutation assay. By means of these assays, we examined the species differences among rodents in the activity and induction rate of hepatic cytochrome P-450 isozymes responsible for the mutagenic activation of carcinogenic aromatic amines.

摘要

通过腹腔注射细胞色素P - 450诱导剂与否，对雄性大鼠、小鼠、仓鼠和豚鼠肝脏微粒体细胞色素P - 450同工酶的表达进行了比较研究。分别采用鼠伤寒沙门氏菌TA98细菌突变试验和使用抗大鼠细胞色素P - 450同工酶单克隆抗体的免疫化学分析法，测定微粒体细胞色素P - 450同工酶的活性和含量。以3 - 甲氧基 - 4 - 氨基偶氮苯（3 - MeO - AAB）、2 - 氨基 - 3 - 甲基 - 9H - 吡啶并[2,3 - b]吲哚乙酸（MeAαC）和3 - 甲基胆蒽作为细胞色素P - 450诱导剂，并将包括3 - MeO - AAB和MeAαC在内的7种致癌芳香胺用作突变试验的底物。通过这些试验，我们研究了啮齿动物之间在负责致癌芳香胺诱变激活的肝脏细胞色素P - 450同工酶活性和诱导率方面的种属差异。