Tanaka M, Satoh T
Department of Oral and Maxillofacial Surgery I, Nippon Dental University School of Dentistry at Tokyo.
Shigaku. 1990 Oct;78(3):527-52.
The models of infection in the rabbits mandible using Streptococcus milleri and Bacteroides fragilis by the method of Satoh-Heimdahl were prepared. A penicillic peroral antimicrobial agent, lenamipicillin (LAPC), and pyridone carboxylic acid peroral antimicrobial agent, tosufloxacin tosilate (TFLX), were administered to infected and healthy groups. Drug concentrations in the serum, pus, mandible, maxilla, humerus, sternum, costa, ilium, femur, tibia, liver, and kidney were determined by a biological method. The data were submitted to pharmacodynamic analysis and compared. The following results were obtained. The concentration of LAPC in the serum and various bone tissues was 1.2-6.4 times higher in the infected group than in the healthy group. The concentration of TFLX in the serum and bone tissues was 1.1-3.7 times higher in the infected group than in the healthy group. Moreover, concentrations in the liver 1.1-fold and 2.1-fold higher in the infectious group than in the healthy group in the LAPC and TFLX administration groups, respectively, and 1.1-fold and 1.3-fold higher in the kidney in the LAPC and TFLX groups, respectively. Both LAPC and TFLX diffused to the pus more satisfactorily than to the serum. The Cmax ratios of pus to infected serum were 1.48 and 1.81 for LAPC and TFLX, respectively, and the AUC ratios of pus to infected serum were 1.31 and 1.62 in LAPC and TFLX, respectively. These results indicated that both LAPC and TFLX are distributed satisfactorily to the local foci in the mandible, and that their systemic diffusion exerted immediate clinical effects.
采用Satoh-Heimdahl法制备了感染米勒链球菌和脆弱拟杆菌的兔下颌骨感染模型。对感染组和健康组给予口服青霉素类抗菌药物仑氨西林（LAPC）和吡啶酮羧酸类口服抗菌药物托氟沙星甲苯磺酸盐（TFLX）。采用生物学方法测定血清、脓液、下颌骨、上颌骨、肱骨、胸骨、肋骨、髂骨、股骨、胫骨、肝脏和肾脏中的药物浓度。对数据进行药效学分析并比较。得到以下结果。感染组血清和各种骨组织中LAPC的浓度比健康组高1.2 - 6.4倍。感染组血清和骨组织中TFLX的浓度比健康组高1.1 - 3.7倍。此外，LAPC和TFLX给药组中，感染组肝脏中的浓度分别比健康组高1.1倍和2.1倍，肾脏中的浓度分别比健康组高1.1倍和1.3倍。LAPC和TFLX扩散到脓液中的效果均比扩散到血清中的效果更好。LAPC和TFLX的脓液与感染血清的Cmax比值分别为1.48和1.81，LAPC和TFLX的脓液与感染血清的AUC比值分别为1.31和1.62。这些结果表明，LAPC和TFLX在下颌骨局部病灶中的分布均良好，且它们的全身扩散发挥了即时临床效果。
