Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Nutr Rev. 2011 Mar;69(3):145-54. doi: 10.1111/j.1753-4887.2011.00373.x. Epub 2011 Feb 14.
Calorie restriction (CR)-induced weight loss has been shown to lower the risk of chronic disease in obese individuals. Although the mechanisms that link weight loss to disease risk reduction remain unclear, evidence suggests adipokines may play a role. What has yet to be determined, however, is the dose-response effect of body weight loss and visceral fat mass loss on adipokines. Accordingly, this review examines how varying degrees of CR-induced weight loss (i.e., >10%, 5-10%, and <5% from baseline) impact plasma levels and expression of adiponectin, leptin, resistin, interleukin 6 (IL-6), interleukin 8 (IL-8), monocyte chemotactic protein 1 (MCP-1), and retinol-binding protein 4 (RBP-4). The dose-response relationship between visceral fat mass loss and adipokine profile improvement will also be explored. Results from this review demonstrate that even mild weight loss induced by CR may have beneficial effects on leptin levels, but it has no clear impact on adiponectin, resistin, IL-6, IL-8, MCP-1, or RBP-4 concentrations.
热量限制（CR）引起的体重减轻已被证明可降低肥胖个体患慢性病的风险。尽管将体重减轻与疾病风险降低联系起来的机制仍不清楚，但有证据表明脂肪因子可能起作用。然而，尚未确定体重减轻和内脏脂肪量减轻对脂肪因子的量效反应。因此，本综述检查了不同程度的 CR 诱导的体重减轻（即，从基线降低> 10％，5-10％和<5％）对脂联素，瘦素，抵抗素，白细胞介素 6（IL-6），白细胞介素 8（IL-8），单核细胞趋化蛋白 1（MCP-1）和视黄醇结合蛋白 4（RBP-4）的血浆水平和表达的影响。还将探讨内脏脂肪质量减轻与脂肪因子谱改善之间的剂量反应关系。本综述的结果表明，即使 CR 引起的轻度体重减轻也可能对瘦素水平有益，但对脂联素，抵抗素，IL-6，IL-8，MCP-1或 RBP-4浓度没有明显影响。
