二甲双胍引起的乳酸酸中毒：一个也不能落下。
Metformin-induced lactic acidosis: no one left behind.
机构信息
Centro Nazionale di Informazione Tossicologica-Centro Antiveleni, IRCCS Fondazione Salvatore Maugeri, Via S. Maugeri 10, 27100 Pavia, Italy.
出版信息
Crit Care. 2011;15(1):107. doi: 10.1186/cc9404. Epub 2011 Jan 21.
Abstract
Metformin is a safe drug when correctly used in properly selected patients. In real life, however, associated lactic acidosis has been repeatedly, although rarely, reported. The term metformin-induced lactic acidosis refers to cases that cannot be explained by any major risk factor other than drug accumulation, usually due to renal failure. Treatment consists of vital function support and drug removal, mainly achieved by renal replacement therapy. Despite dramatic clinical presentation, the prognosis of metformin-induced lactic acidosis is usually surprisingly good.
摘要
二甲双胍在正确使用且选择合适的患者中是一种安全的药物。然而，在现实生活中，尽管罕见，但已反复报告与该药物相关的乳酸酸中毒。二甲双胍引起的乳酸酸中毒是指除药物蓄积外，不能用任何主要危险因素解释的病例，通常是由于肾衰竭引起的。治疗包括生命功能支持和药物清除，主要通过肾脏替代疗法来实现。尽管临床表现明显，但二甲双胍引起的乳酸酸中毒的预后通常出人意料地良好。
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