Hogan N A, Hill H R
J Infect Dis. 1978 Oct;138(4):437-44. doi: 10.1093/infdis/138.4.437.
Levamisole, an antihelminthic agent reported to enhance nonspecifically various parameters of the immune response, was examined for its effect on chemotaxis of human neutrophils and on levels of cellular cyclic nucleotides. This agent was found, in most instances, to enhance chemotactic responses of neutrophils to a bacterial chemotactic factor derived from Escherichia coli. At similar concentrations, levamisole produced increases in levels of guanosine 3':5'-cyclic phosphate in neutrophils. In contrast, a decrease in concentrations of adenosine 3':5'-cyclic phosphate was observed when neutrophils were incubated with levamisole. Neutrophil chemotaxis, with and without the addition of levamisole, was assessed in 10 patients with recurrent infections. The illnesses of these patients included Job's syndrome, Wiskott-Aldrich syndrome, eczema with an increased level of IgE and recurrent abscesses, chronic mucocutaneous candidiasis, and diabetes mellitus. Levamisole significantly enhanced chemotaxis of polymorphonuclear leukocytes from these patients. Levamisole appears to have a profound effect on chemotactic responses of neutrophils which probably results from alterations in cellular cyclic nucleotide levels. Levamisole may prove to be useful therapeutically in certain patients with defective neutrophil chemotaxis.
左旋咪唑是一种据报道可非特异性增强免疫反应各项参数的抗蠕虫药，我们研究了它对人中性粒细胞趋化性以及细胞环核苷酸水平的影响。在大多数情况下，发现该药物可增强中性粒细胞对源自大肠杆菌的细菌趋化因子的趋化反应。在相似浓度下，左旋咪唑可使中性粒细胞中的鸟苷3':5'-环磷酸水平升高。相反，当中性粒细胞与左旋咪唑一起孵育时，观察到腺苷3':5'-环磷酸浓度降低。在10例反复感染患者中评估了添加和不添加左旋咪唑时的中性粒细胞趋化性。这些患者的疾病包括乔布综合征、维斯科特-奥尔德里奇综合征、IgE水平升高且反复出现脓肿的湿疹、慢性黏膜皮肤念珠菌病以及糖尿病。左旋咪唑显著增强了这些患者多形核白细胞的趋化性。左旋咪唑似乎对中性粒细胞的趋化反应有深远影响，这可能是由细胞环核苷酸水平的改变导致的。左旋咪唑可能在某些中性粒细胞趋化性缺陷的患者中被证明具有治疗作用。
