Rabson A R, Whiting D A, Anderson R, Glover A, Koornhof H J
J Infect Dis. 1977 Jan;135(1):113-6. doi: 10.1093/infdis/135.1.113.
The random migration and chemotaxis of neutrophils from 10 patients with recurrent infections with herpes simplex virus were assessed. Chemotaxis to endotoxin-activated serum was markedly diminished in this group, but random migration was only mildly reduced, and chemotaxis to hydrolyzed casein was normal. The effects of the immunostimulant drug levamisole on the chemotaxis of neutrophils were assessed both in vitro and in patients after 150 mg of the drug was taken daily for three days. The defective chemotactic response could be corrected in vitro by treatment of the neutrophils with 10(-3) M levamisole. Of 10 patients treated with levamisole, five showed improved chemotaxis after three days, but no improvement in neutrophil function was observed in the other patients.
对10例复发性单纯疱疹病毒感染患者的中性粒细胞随机迁移和趋化性进行了评估。该组患者对内毒素激活血清的趋化性明显降低，但随机迁移仅轻度减少，对水解酪蛋白的趋化性正常。在体外以及在患者每日服用150毫克免疫刺激药物左旋咪唑三天后，评估了其对中性粒细胞趋化性的影响。用10(-3)M左旋咪唑处理中性粒细胞可在体外纠正有缺陷的趋化反应。在接受左旋咪唑治疗的10例患者中，5例在三天后趋化性有所改善，但其他患者未观察到中性粒细胞功能改善。
