Department of Obstetrics and Gynecology, Brigham & Women's Hospital, Boston, MA, USA.
Am J Obstet Gynecol. 2011 May;204(5):418.e1-418.e12. doi: 10.1016/j.ajog.2010.12.010. Epub 2011 Feb 24.
Disorders that lead to preterm delivery influence the fetal inflammatory response.
We calculated odds ratios of elevated concentrations of 25 blood proteins on the first postnatal day in 798 infants born before the 28th week and classified by the pregnancy disorder that lead to preterm delivery.
Concentrations of cytokines (IL-1β, IL-6, TNFα), cytokine receptors (IL-6R, TNF-R1, TNF-R2), systemic inflammatory proteins (CRP, SAA, MPO), chemokines (IL-8, MCP-1, MCP-4, MIP-1β, RANTES, I-TAC), adhesion molecules (ICAM-1, ICAM-3, VCAM-1, E-selectin), and metalloproteinases (MMP-1, MMP-9) were elevated in children delivered after preterm labor, membrane rupture, abruption, and cervical insufficiency, whereas such a pattern was not seen after preeclampsia or fetal indication/growth restriction. Inflammatory profiles were also associated with maternal vaginitis.
The patterns of blood proteins in the newborn support the division of pregnancy disorders that lead to preterm delivery into those associated, and those not associated, with inflammation.
导致早产的疾病会影响胎儿的炎症反应。
我们计算了 798 名在第 28 周前出生的婴儿在出生后第 1 天血液中 25 种蛋白质浓度升高的比值，这些婴儿根据导致早产的妊娠疾病进行了分类。
细胞因子（IL-1β、IL-6、TNFα）、细胞因子受体（IL-6R、TNF-R1、TNF-R2）、全身性炎症蛋白（CRP、SAA、MPO）、趋化因子（IL-8、MCP-1、MCP-4、MIP-1β、RANTES、I-TAC）、粘附分子（ICAM-1、ICAM-3、VCAM-1、E-选择素）和金属蛋白酶（MMP-1、MMP-9）在早产、胎膜早破、胎盘早剥和宫颈机能不全的新生儿中升高，而子痫前期或胎儿指征/生长受限的新生儿则没有这种模式。炎症谱也与母亲阴道炎有关。
新生儿血液蛋白的模式支持将导致早产的妊娠疾病分为与炎症相关和不相关的疾病。
