老年人扩张性 Virchow-Robin 空间的频率和位置：一项基于人群的 3D MR 成像研究。
Frequency and location of dilated Virchow-Robin spaces in elderly people: a population-based 3D MR imaging study.
机构信息
From INSERM U708, Paris, France.
出版信息
AJNR Am J Neuroradiol. 2011 Apr;32(4):709-13. doi: 10.3174/ajnr.A2366. Epub 2011 Feb 24.
BACKGROUND AND PURPOSE
dVRS have been previously associated with aging and cerebrovascular diseases. However, little is known about their prevalence and topographic distribution in the general elderly population.
MATERIALS AND METHODS
dVRS were evaluated by using high-resolution 3D MR imaging in 1826 subjects enrolled in the 3C-Dijon MR imaging study. On T1-weighted MR imaging, dVRS were detected according to 3D imaging criteria and rated by using 4-level severity scores based in the BG or in the WM. The number and anatomic location of large dVRS (≥3 mm) were recorded.
RESULTS
dVRS were observed in the BG or WM in every subject. The severity of dVRS was significantly associated with higher age in both the BG and WM, whereas sex was related to the severity of dVRS only in the BG. Large dVRS were detected in 33.2% of participants. Status cribrosum was found in 1.3% of participants. dVRS were also highly prevalent within the hippocampus (44.5%) and hypothalamus (11.6%).
CONCLUSIONS
dVRS are always detected in the BG or WM in elderly people, and large dVRS are also prevalent. The topographic distribution of dVRS is not uniform within the brain and may depend on anatomic or pathologic characteristics interacting with aging and sex.
背景与目的
dVRS 以前与衰老和脑血管疾病有关。然而，关于它们在一般老年人群中的流行率和拓扑分布知之甚少。
材料与方法
在 3C-Dijon 磁共振成像研究中，对 1826 名受试者进行了高分辨率 3D MR 成像评估 dVRS。在 T1 加权 MR 成像上，根据 3D 成像标准检测 dVRS，并根据基于 BG 或 WM 的 4 级严重程度评分进行评分。记录大 dVRS（≥3mm）的数量和解剖位置。
结果
在每个受试者的 BG 或 WM 中都观察到 dVRS。在 BG 和 WM 中，dVRS 的严重程度均与年龄的增加显著相关，而性别仅与 BG 中 dVRS 的严重程度相关。33.2%的参与者检测到大 dVRS。在 1.3%的参与者中发现筛状。dVRS 在海马体（44.5%）和下丘脑（11.6%）中也非常普遍。
结论
老年人的 BG 或 WM 中总是检测到 dVRS，大 dVRS 也很常见。dVRS 的拓扑分布在大脑内并不均匀，可能取决于与衰老和性别相互作用的解剖或病理特征。
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