Storozheva Z I, Kirenskaia A V, Lazarev I E, Novototskiĭ-Vlasov V Iu, Samylkin D V, Fastovtsov G A
Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(2):72-5.
Prepulse modification of acoustic startle reaction (ASR) was studied in patients with schizophrenia and healthy controls according to the protocol recommended by the Consortium on the genetics of schizophrenia. Patients displayed the reduced ASR magnitude of prepulse inhibition (PPI) and increased startle latency prepulse facilitation (PPF) at 60 ms lead interval. The ASR amplitude PPF at 2500 ms lead interval was also impaired in patients. Effects of the recent head trauma and psychoactive drug experience on the ASR prepulse modification were different in patients and controls. The high baseline amplitude and short ASR latency in patients were correlated with the excitation level measured with the PANSS (item P4) whereas the PPF reduction was correlated with the high total score on the PANSS positive subscale. These results suggest the possibility of using ASR prepulse modification in clinical neurophysiology.
根据精神分裂症遗传学联盟推荐的方案，对精神分裂症患者和健康对照者的听觉惊吓反应（ASR）的预脉冲调制进行了研究。患者在60毫秒超前间隔时表现出预脉冲抑制（PPI）的ASR幅度降低，以及惊吓潜伏期预脉冲易化（PPF）增加。患者在2500毫秒超前间隔时的ASR幅度PPF也受损。近期头部创伤和精神活性药物体验对ASR预脉冲调制的影响在患者和对照者中有所不同。患者的高基线幅度和短ASR潜伏期与用阳性和阴性症状量表（PANSS，项目P4）测量的兴奋水平相关，而PPF降低与PANSS阳性分量表的高总分相关。这些结果表明在临床神经生理学中使用ASR预脉冲调制的可能性。
