Kirenskaya A V, Storozheva Z I, Ilyushina E A, Tkatchenko A A
Serbsky National Medical Research Centre for Psychiatry and Narcology, Moscow, Russia.
Serbsky National Medical Research Centre for Psychiatry and Narcology, Moscow, Russia; Sechenov First Moscow State Medical University, Moscow, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2020;120(2):45-52. doi: 10.17116/jnevro202012002145.
To study the early stages of sensory (P50 suppression) and sensorimotor (prepulse modification of acoustic startle reaction - ASR) information processing in aggressive and non-aggressive patients with schizophrenia.
Two groups (aggressive group A, 44 s. and non-aggressive group NA, 27 s.) and 48 healthy people were studied using oculography and encephalography. Symptoms of schizophrenia were assessed by PANSS.
The analysis of ASR and P50 revealed the increased ASR latency, deficit of prepulse inhibition (PPI) with 60 ms leading interval, and P50 suppression in patients compared to controls. Aggressive behavior impacted on lateral features of ASR changes in the group A. The increase of ASR amplitude and the decline of prepulse facilitation were found in the group NA. The P50 analysis revealed the increased P50 amplitude and the shortened latency in response to 2nd stimulus in the pair. The increase in scores on item G14 of the PANSS (Poor impulse control) in the group A and its correlations with ASR and P50 parameters in this group suggested the important role of impulsivity in aggressive behavior in the studied sample of aggressive patients. ASR and P50 characteristics in the group NA are associated with increased sensitivity to incoming stimuli and such personality traits as increased alertness and fear, which might inhibit aggression. Thus, indicators of the early stages of information processing can be considered as potential predictors of aggressive behavior.
研究精神分裂症攻击型和非攻击型患者感觉（P50抑制）和感觉运动（听觉惊吓反应的预脉冲调制 - ASR）信息处理的早期阶段。
使用眼动图和脑电图对两组患者（攻击型A组，44例；非攻击型NA组，27例）以及48名健康人进行研究。采用阳性和阴性症状量表（PANSS）评估精神分裂症症状。
与对照组相比，对ASR和P50的分析显示患者的ASR潜伏期延长、60毫秒前导间隔的预脉冲抑制（PPI）缺陷以及P50抑制。攻击行为影响了A组ASR变化的侧向特征。在NA组中发现ASR幅度增加和预脉冲促进作用下降。P50分析显示对成对中的第二个刺激的反应中P50幅度增加且潜伏期缩短。A组中PANSS的G14项（冲动控制差）得分增加及其与该组中ASR和P50参数的相关性表明冲动性在攻击型患者研究样本中的攻击行为中起重要作用。NA组中的ASR和P50特征与对传入刺激的敏感性增加以及诸如警觉性和恐惧增加等人格特质相关，这可能会抑制攻击行为。因此，信息处理早期阶段的指标可被视为攻击行为的潜在预测指标。
