Storozheva Zinaida I, Kirenskaya Anna V, Novototsky-Vlasov Vladimir Y, Telesheva Klavdia Y, Pletnikov Mikhail
Serbsky National Research Centre for Social and Forensic Psychiatry (Russia).
Johns Hopkins University School of Medicine (USA).
Span J Psychol. 2016 Mar 3;19:E8. doi: 10.1017/sjp.2016.1.
Prepulse modification of the acoustic startle response (ASR) and P50 gating are potential neurophysiological endophenotypes of schizophrenia and may be used in the construction of valid clinical biomarkers. Such approach requires a large amount of data obtained in the representative samples from different gender, socio-typological and ethnic groups, replicating studies using the similar protocols and meta-analyses. This is a replication study of ASR and the first study of P50 suppression in Russian patients with schizophrenia (n = 28) and healthy controls (n = 25). ASR and P50 were estimated according to standard protocols. Patients exhibited increased baseline ASR latency (d = 0.35, p = .026) and reduced prepulse inhibition (PPI) at 60 ms interval (d = 0.39, p = .003) and 120 ms interval (d = 0.37, p = .005) relative to controls. In the P50 test patients displayed greater S2 response amplitude (d = 0.24, p = .036) and deficit of P50 suppression (d = 0.43, p = .001). No correlations of PPI and P50 suppression were found in both groups. Only in controls prepulse ASR facilitation (at 2500 ms interval) positively correlated with P50 suppression (r = -.514, p = .013). In patients PPI displayed significant correlations with Difficulty in abstract thinking (N5: r = -.49, p = .005) and Hallucination (P3: r = .40, p = .036) PANSS scales. Logistic regression showed that the combination of PPI and P50 suppression could serve as a diagnostic predictor. Obtained results demonstrated that both PPI and P50 could be regarded as potential schizophrenia biomarkers in Russian population.
听觉惊吓反应（ASR）的预脉冲调节和P50门控是精神分裂症潜在的神经生理内表型，可用于构建有效的临床生物标志物。这种方法需要从不同性别、社会类型和种族群体的代表性样本中获取大量数据，使用相似方案进行重复研究和荟萃分析。这是一项针对俄罗斯精神分裂症患者（n = 28）和健康对照者（n = 25）的ASR重复研究以及P50抑制的首次研究。ASR和P50根据标准方案进行评估。与对照组相比，患者表现出基线ASR潜伏期增加（d = 0.35，p = 0.026），在60毫秒间隔时预脉冲抑制（PPI）降低（d = 0.39，p = 0.003），在120毫秒间隔时也降低（d = 0.37，p = 0.005）。在P50测试中，患者表现出更大的S2反应幅度（d = 0.24，p = 0.036）和P50抑制缺陷（d = 0.43，p = 0.001）。两组中均未发现PPI与P50抑制之间存在相关性。仅在对照组中，预脉冲ASR促进（在2500毫秒间隔时）与P50抑制呈正相关（r = -0.514，p = 0.013）。在患者中，PPI与阳性和阴性症状量表（PANSS）中的抽象思维困难（N5：r = -0.49，p = 0.005）和幻觉（P3：r = 0.40，p = 0.036）量表存在显著相关性。逻辑回归表明，PPI和P50抑制的组合可作为诊断预测指标。获得的结果表明，PPI和P50在俄罗斯人群中均可被视为潜在的精神分裂症生物标志物。
