Kondo K
Department of Pathology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan.
Aichi Gakuin Daigaku Shigakkai Shi. 1990 Mar;28(1 Pt 1):123-57.
The purpose of the present study was to investigate histologically and histometrically the effect of experimental unilateral traumatic occlusion (right side) on the mandibular condyle in rats. 1. Histological findings of the periodontal tissues. i. Group A (Control Group) Periodontal tissues of the right mandibular first molar: Throughout the entire experimental period, a normal structure was observed. ii. Group B (1 mm Group) Periodontal tissues of the right mandibular first molar: At 1 and 2 weeks, resorption of the dentin and cementun, irregular arrangement of the periodontal fibers, resorption of the alveolar bone, and widening of the periodontal space were observed. At 3 and 4 weeks, these changes were gradually repaired. At 8 weeks, the changes were almost repaired except the change of the alveolar bone. Periodontal tissues of the left mandibular first molar: Throughout the entire experimental period, no changes were found. iii. Group C (2 mm Group) Periodontal tissues of the right mandibular first molar: At 1 and 2 weeks, resorption of the dentin and cementum, irregular arrangement of the periodontal fibers, necrosis of the periodontal ligament, resorption of the alveolar bone, and widening of the periodontal space were observed. These changes were more marked than those of the same molar in Group B. From 3 to 8 weeks, the changes were similar to those of the same molar in Group B. Periodontal tissues of the left mandibular first molar: Throughout the entire experimental period, no changes were found. 2. Histological and histometrical findings of the mandibular condyles. i. Group B (1 mm Group) Right mandibular condyle: The layers of differentiation and hypertrophy showed a marked decrease in thickness and cellularity at 4 and 8 weeks. The layer of cartilage decreased significantly in thickness at 4 and 8 weeks (p less than 0.01). The cancellous bone showed a marked widening of bone marrow spaces at 4 and 8 weeks. It also decreased significantly in volumetric density at 4 and 8 weeks (p less than 0.01 or p less than 0.05). Left mandibular condyle: The layers of differentiation and hypertrophy showed a marked decrease in thickness and cellularity at 4 and 8 weeks. The layer of cartilage decreased significantly in thickness at 4 and 8 weeks (p less than 0.01). ii. Group C (2 mm Group) Right mandibular condyle: The layer of articular surface showed a marked decrease in cellularity at 1, 2, 3 and 8 weeks. It also decreased significantly in thickness at 1, 2, 3 and 8 weeks (p less than 0.05).(ABSTRACT TRUNCATED AT 400 WORDS)
本研究的目的是从组织学和组织计量学角度研究实验性单侧创伤性咬合（右侧）对大鼠下颌髁突的影响。1. 牙周组织的组织学发现。i. A组（对照组）：右侧下颌第一磨牙的牙周组织：在整个实验期间，观察到结构正常。ii. B组（1毫米组）：右侧下颌第一磨牙的牙周组织：在第1周和第2周，观察到牙本质和牙骨质吸收、牙周纤维排列不规则、牙槽骨吸收以及牙周间隙增宽。在第3周和第4周，这些变化逐渐修复。在第8周，除牙槽骨变化外，其他变化几乎已修复。左侧下颌第一磨牙的牙周组织：在整个实验期间，未发现变化。iii. C组（2毫米组）：右侧下颌第一磨牙的牙周组织：在第1周和第2周，观察到牙本质和牙骨质吸收、牙周纤维排列不规则、牙周韧带坏死、牙槽骨吸收以及牙周间隙增宽。这些变化比B组同一磨牙的变化更明显。从第3周到第8周，变化与B组同一磨牙的变化相似。左侧下颌第一磨牙的牙周组织：在整个实验期间，未发现变化。2. 下颌髁突的组织学和组织计量学发现。i. B组（1毫米组）：右侧下颌髁突：在第4周和第8周，分化层和肥大层的厚度和细胞数量显著减少。软骨层在第4周和第8周厚度显著减小（p<0.01）。松质骨在第4周和第8周骨髓腔明显增宽。其体积密度在第4周和第8周也显著降低（p<0.01或p<0.05）。左侧下颌髁突：在第4周和第8周，分化层和肥大层的厚度和细胞数量显著减少。软骨层在第4周和第8周厚度显著减小（p<0.01）。ii. C组（2毫米组）：右侧下颌髁突：在第1周、第2周、第3周和第8周，关节表面层细胞数量显著减少。在第1周、第2周、第3周和第8周，其厚度也显著减小（p<0.05）。（摘要截选至400字）
