Stavri D, Niculescu D, Stavri H, Tipărescu E, Constantin S, Fuiorea I, Basacopol A
Cantacuzino Institute, Bucharest, Romania.
Arch Roum Pathol Exp Microbiol. 1990 Oct-Dec;49(4):323-9.
206 sera collected from different groups of subjects were analyzed by immunoenzymatic methods regarding the content of Mycobacterium tuberculosis specific antibodies and mycobacterial antigens. The results underlined that two assays offered improved serologic diagnosis of tuberculosis over a single antibody test. BCG vaccination interferes with serologic tests for tuberculosis when polyspecific antibodies or mixture of common and specific antigens are used as immunologic reagents. A mycobacterial antigens circadian variation in correlation with vesperal fever in tuberculous patients was not revealed. The mycobacterial antigens seem to become undetectable, in sera, after 6 months of efficient treatment.
采用免疫酶法分析了从不同受试者组收集的206份血清中结核分枝杆菌特异性抗体和分枝杆菌抗原的含量。结果表明，两种检测方法在结核病血清学诊断方面比单一抗体检测有更好的效果。当使用多特异性抗体或常见抗原与特异性抗原的混合物作为免疫试剂时，卡介苗接种会干扰结核病的血清学检测。未发现结核患者中分枝杆菌抗原的昼夜变化与傍晚发热相关。在有效治疗6个月后，血清中的分枝杆菌抗原似乎无法检测到。
