人类阴茎尿道中的先天和获得性免疫。
Innate and acquired immunity in the human penile urethra.
机构信息
Department of Obstetrics and Gynecology, Boston University, School of Medicine, Boston, MA 02118, USA.
出版信息
J Reprod Immunol. 2011 Mar;88(2):219-27. doi: 10.1016/j.jri.2011.01.006. Epub 2011 Feb 24.
Abstract
In men, the penile urethra is a primary infection site for sexually transmitted pathogens. Research on the immunology of this mucosal site has been limited in part due to sampling challenges, but available evidence indicates that the urethra contains a rich contingent of immunological mediators that can mount vigorous innate and adaptive immune responses against infectious organisms. Further research is needed to define approaches to stimulate immunity at this mucosal site to prevent the transmission of HIV-1 and other sexually transmitted pathogens.
摘要
在男性中，阴茎尿道是性传播病原体的主要感染部位。由于采样方面的挑战，对该黏膜部位免疫学的研究受到一定限制，但现有证据表明，尿道含有丰富的免疫介质，可以对感染性生物体产生强烈的先天和适应性免疫反应。需要进一步研究来确定刺激该黏膜部位免疫的方法，以预防 HIV-1 和其他性传播病原体的传播。
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