Poulose Divya, Lote Samruddhi, Mahajan Aditi, Gogineni Jaya Madhurya
Dermatology, Dr. D.Y. Patil Medical College Hospital and Research Centre, Pune, IND.
Dermatology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Pune, IND.
Cureus. 2021 Jul 28;13(7):e16683. doi: 10.7759/cureus.16683. eCollection 2021 Jul.
Infantile hemangiomas (IHs) are the most common vascular soft-tissue tumors of newborns and early childhood with a prevalence rate of approximately 4%-5% in infancy. Most of the IHs regress spontaneously after initial proliferation. Ulceration is one of the most common complications seen in IHs, which heal poorly without treatment. The prevalence of IHs is three times more in females compared to males. The most common location of IH is head and neck with the least being in extremities Oral propranolol and systemic corticosteroids are used as first-line therapy in the treatment. Topical timolol has been used as an alternative to counteract the long-term side effects of the prior modalities. In this study, we are reporting and presenting case reports of two female infants with ulcerated IH who were treated with oral propranolol and topical timolol, respectively, and comparing the efficacy of one over the other. we observed fast and efficacious healing with oral propranolol when used with proper monitoring, as compared to topical timolol, although the latter is more commonly used as it is safer with fewer potential side effects.
婴儿血管瘤（IHs）是新生儿和幼儿期最常见的血管软组织肿瘤，在婴儿期的患病率约为4%-5%。大多数婴儿血管瘤在最初增殖后会自发消退。溃疡是婴儿血管瘤最常见的并发症之一，未经治疗很难愈合。婴儿血管瘤的患病率女性是男性的三倍。婴儿血管瘤最常见的部位是头颈部，四肢最少见。口服普萘洛尔和全身用糖皮质激素被用作治疗的一线疗法。局部用噻吗洛尔已被用作替代疗法，以对抗先前治疗方式的长期副作用。在本研究中，我们报告并展示了两名患有溃疡型婴儿血管瘤的女婴的病例报告，她们分别接受了口服普萘洛尔和局部用噻吗洛尔治疗，并比较了两者的疗效。我们观察到，与局部用噻吗洛尔相比，口服普萘洛尔在适当监测下使用时愈合迅速且有效，尽管后者因更安全、潜在副作用更少而更常用。
