Kono K, Yoshida Y, Watanabe M, Watanabe H, Inoue S, Tanioka Y, Dote T, Orita Y, Umebayashi K, Tanimura Y
Department of Hygiene and Public Health, Osaka Medical College, Japan.
Bull Osaka Med Coll. 1990 Nov;36(1-2):27-34.
In this paper, the normal values, distribution, and variations in serum and urinary activities of the lysosomal enzyme, N-acetyl-beta-D-glucosaminidase (NAG), were estimated in a rural area of Japan. The frequency distribution of NAG activities both in the serum and urine of 1,152 males and females (aged 35 to 87), living in a rural area of Gifu Prefecture in Japan, showed an approximately log-normal distribution. Geometric mean values (with S.D. ranges) in healthy subjects (876 males and females) were 12.61 U/l (9.56-16.63) for serum NAG and 8.05 U/l (4.03-16.07) for urinary NAG. There was no significant difference between those of males and females. Serum and urinary NAG activities increased with advancing ages, and these NAG activities in hypertensive subjects were higher than those in normotensives. Since the serum and urinary levels of several commonly measured cytosolic chemicals were within normal limits, the above results could not be ascribed to tissue necrosis. Thus, the estimation of serum and urinary NAG could be a useful indicator discriminating the essential hypertensive patients from the normal subjects.
本文对日本某农村地区溶酶体酶N - 乙酰 - β - D - 氨基葡萄糖苷酶（NAG）的血清和尿液活性的正常值、分布及变化情况进行了评估。居住在日本岐阜县某农村地区的1152名男性和女性（年龄在35至87岁之间）的血清和尿液中NAG活性的频率分布呈近似对数正态分布。健康受试者（876名男性和女性）的血清NAG几何平均值（标准差范围）为12.61 U/l（9.56 - 16.63），尿液NAG为8.05 U/l（4.03 - 16.07）。男性和女性之间无显著差异。血清和尿液NAG活性随年龄增长而升高，高血压患者的这些NAG活性高于血压正常者。由于几种常用的细胞溶质化学物质的血清和尿液水平在正常范围内，上述结果不能归因于组织坏死。因此，血清和尿液NAG的评估可能是区分原发性高血压患者和正常受试者的有用指标。
