Chole Revant H, Patil Ranjitkumar N, Basak Anjan, Palandurkar Kamlesh, Bhowate Rahul
Department of Oral Medicine and Radiology, Peoples Dental Academy, Bhopal, Madhya Pradesh, India.
J Cancer Res Ther. 2010 Oct-Dec;6(4):487-91. doi: 10.4103/0973-1482.77106.
Tobacco and alcohol induces generation of free radicals and reactive oxygen species, which are responsible for high rate of lipid peroxidation. Malondialdehyde is the most widely used marker of lipid peroxidation. The aim of the study was to estimate serum malondialdehyde level in oral precancer, oral cancer, and normal individuals.
In this study serum malondialdehyde was measured according to the method of Ohkawa et al in 30 normal individuals and 30 patients each with histopathologically diagnosed oral precancer, and oral cancer.
The mean serum malondialdehyde level in the control group was found to be 5.107 ± 2.32 ηmol/ml, whereas it was 9.33 ± 4.89 ηmol/ml and 14.34 ± 1.43 ηmol/ml in oral precancer and oral cancer, respectively. There was statistically significant increase in serum malondialdehyde levels in the oral precancer and oral cancer patients compared with the control group.
Increased serum malondialdehyde in oral cancer and oral precancer would serve as a valuable marker for both preventive and clinical intervention, and may deserve further investigation for the early diagnosis, treatment, and prognosis.
烟草和酒精会诱导自由基和活性氧的产生，而自由基和活性氧会导致脂质过氧化率升高。丙二醛是脂质过氧化最常用的标志物。本研究的目的是评估口腔癌前病变、口腔癌患者及正常个体的血清丙二醛水平。
本研究采用大川等人的方法，对30名正常个体以及各30名经组织病理学诊断为口腔癌前病变和口腔癌的患者进行血清丙二醛检测。
对照组血清丙二醛平均水平为5.107±2.32纳摩尔/毫升，而口腔癌前病变组和口腔癌组分别为9.33±4.89纳摩尔/毫升和14.34±1.43纳摩尔/毫升。与对照组相比，口腔癌前病变患者和口腔癌患者的血清丙二醛水平有统计学意义的升高。
口腔癌和口腔癌前病变患者血清丙二醛水平升高，可作为预防和临床干预的重要标志物，在早期诊断、治疗及预后方面可能值得进一步研究。
